人肾线粒体中二羟基化维生素D代谢产物的合成
The synthesis of dihydroxylated vitamin D metabolites by human renal mitochondria.
作者信息
White C P, Richardson R H, Posen S
出版信息
J Clin Endocrinol Metab. 1981 Aug;53(2):450-2. doi: 10.1210/jcem-53-2-450.
PMID:6972950
Abstract
Mitochondrial preparations from 4 human kidneys produced 1,25-dihydroxycholecalciferol and 24,25 dihydroxycholecalciferol at rates of 0.019 - 0.114 and 0.029 - 0.164 pmol/mg/min respectively at a 25-hydroxycholecalciferol concentration of 1 mumol per litre. Mitochondria from a fifth kidney failed to produce either metabolite.
摘要
来自4个人类肾脏的线粒体提取物，在25-羟胆钙化醇浓度为每升1微摩尔时，分别以0.019 - 0.114和0.029 - 0.164皮摩尔/毫克/分钟的速率产生1,25-二羟胆钙化醇和24,25-二羟胆钙化醇。来自第五个肾脏的线粒体未能产生任何一种代谢物。
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