肾功能不全患者体内[6-³H]1α-羟胆钙化醇向[6-³H]1α,25-二羟胆钙化醇的代谢情况
The metabolism of [6-3H]1alpha, hydroxycholecalciferol to [6-3H]1alpha,25-dihydroxycholecalciferol in a patient with renal insufficiency.
作者信息
Holick M F, de Blanco M C, Clark M B, Henley J W, Neer R M, DeLuca H F, Potts J T
出版信息
J Clin Endocrinol Metab. 1977 Mar;44(3):595-8. doi: 10.1210/jcem-44-3-595.
To evaluate whether 1alpha-hydroxycholecalciferol is metabolized to 1alpha,25-dihydroxycholecalciferol in man, [6-3H]1alpha-hydroxycholecalciferol was given intravenously to a patient with renal failure who was maintained daily on 100,000 IU vitamin D and calcium supplements. Using Sephadex LH-20 and high-pressure liquid chromatography, it was clearly demonstrated that 1alpha-hydroxycholecalciferol rapidly disappears from the blood and is metabolized to 1alpha,25-dihydroxycholecalciferol.
为评估1α-羟胆钙化醇在人体内是否会代谢为1α,25-二羟胆钙化醇，将[6-³H]1α-羟胆钙化醇静脉注射给一名肾衰竭患者，该患者每日维持服用100,000国际单位维生素D及钙剂。使用葡聚糖凝胶LH-20和高压液相色谱法，明确证实1α-羟胆钙化醇迅速从血液中消失并代谢为1α,25-二羟胆钙化醇。
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