对感染新城疫病毒的小鼠中调节接触敏感性的T抑制细胞回路的分析。
Analysis of the T suppressor cell circuit which regulates contact sensitivity in mice infected with the virus of Newcastle disease.
作者信息
Salerno A, Colonna Romano G, Dieli F, Colizzi V
出版信息
Immunology. 1984 Feb;51(2):305-11.
The interaction between the virus of Newcastle disease (NDV) and the different cellular elements involved in the T suppressor cell circuit which regulates the expression phase of contact sensitivity has been investigated. NDV does not interfere with the production of the antigen-specific T suppressor factor (TsF) but inhibits its binding to T acceptor cells (Tacc). This cell when armed with TsF and exposed to the antigen corresponding to TsF releases a non-specific inhibitor of the transfer of contact sensitivity. More detailed analysis of the effect of NDV on the Tacc system showed that not only Tacc activity is impaired by NDV, but also the ability of antigen presenting cells (APC) to trigger Tacc armed with TsF is inhibited. The impairment of APC activity by NDV has been also investigated using another system, such as the induction of contact sensitivity by footpad cell transfer. The possibility that a virus-induced membrane modification might be responsible for the effect of NDV on the regulation of contact sensitivity is discussed.
新城疫病毒（NDV）与参与调节接触敏感性表达阶段的T抑制细胞回路中不同细胞成分之间的相互作用已得到研究。新城疫病毒不干扰抗原特异性T抑制因子（TsF）的产生，但会抑制其与T受体细胞（Tacc）的结合。当这种细胞携带TsF并暴露于与TsF对应的抗原时，会释放一种接触敏感性传递的非特异性抑制剂。对新城疫病毒对Tacc系统影响的更详细分析表明，新城疫病毒不仅会损害Tacc活性，还会抑制抗原呈递细胞（APC）触发携带TsF的Tacc的能力。还使用另一种系统，如通过足垫细胞转移诱导接触敏感性，研究了新城疫病毒对APC活性的损害。讨论了病毒诱导的膜修饰可能是新城疫病毒对接触敏感性调节产生影响的原因。
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