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诺龙、睾酮及其癸酸酯对小鼠狼疮的影响。

The effects of nandrolone, testosterone and their decanoate esters on murine lupus.

作者信息

Verheul H A, Stimson W H, den Hollander F C, Schuurs A H

出版信息

Clin Exp Immunol. 1981 Apr;44(1):11-7.

Abstract

Treatment of NZB/NZW F1 (B/W) female and castrated male mice with testosterone or 19-nortestosterone (nandrolone), either by implantation in silastic tubing or by subcutaneous injections of their decanoate esters, reduced in a dose-dependent manner symptoms associated with murine lupus (proteinuria, IgG antibodies to DNA) and prolonged survival. These phenomena were observed under both prophylactic (start at 3-4 weeks) and therapeutic treatments (start 27-29 weeks). Nandrolone and its decanoate ester were at least as potent as testosterone and testosterone decanoate. As the unwanted androgenic properties of nandrolone and its ester are significantly less pronounced than those of testosterone and its ester, also in these NZB/NZW mice, the beneficial effect on murine lupus does not seem to be associated with these properties.

摘要

通过硅橡胶管植入或皮下注射癸酸酯,用睾酮或19-去甲睾酮(诺龙)治疗NZB/NZW F1(B/W)雌性和去势雄性小鼠,可剂量依赖性地减轻与小鼠狼疮相关的症状(蛋白尿、抗DNA IgG抗体)并延长生存期。在预防性治疗(3-4周开始)和治疗性治疗(27-29周开始)中均观察到了这些现象。诺龙及其癸酸酯至少与睾酮和睾酮癸酸酯一样有效。由于诺龙及其酯的不良雄激素特性明显不如睾酮及其酯,在这些NZB/NZW小鼠中也是如此,对小鼠狼疮的有益作用似乎与这些特性无关。

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