棒状链霉菌中头孢菌素产生的碳分解代谢调控
Carbon catabolite regulation of cephalosporin production in Streptomyces clavuligerus.
作者信息
Aharonowitz Y, Demain A L
出版信息
Antimicrob Agents Chemother. 1978 Aug;14(2):159-64. doi: 10.1128/AAC.14.2.159.
Abstract
Cephalosporin production by Streptomyces clavuligerus is regulated by some type of carbon catabolite control. Increasing concentrations of preferred carbon sources, such as glycerol and maltose, decreased production of the antibiotics. Poorer carbon sources, such as alpha-ketoglutarate and succinate, led to high specific production of cephalosporins and shifted the dynamics of fermentation to a greater degree of association with growth. The results support the concept that the phase in which a product is made by a microorganism is not a function of the particular molecule produced, but rather of the nutritional environment presented to the organism.
摘要
棒状链霉菌产生头孢菌素受某种碳分解代谢物控制类型的调节。增加优选碳源（如甘油和麦芽糖）的浓度会降低抗生素的产量。较差的碳源（如α-酮戊二酸和琥珀酸）会导致头孢菌素的高比产量，并使发酵动力学在更大程度上与生长相关联。这些结果支持了这样一种概念，即微生物产生产物的阶段不是所产生的特定分子的函数，而是呈现给生物体的营养环境的函数。
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