Jermini M F, Demain A L
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.
Experientia. 1989 Dec 1;45(11-12):1061-5. doi: 10.1007/BF01950159.
Solid state fermentation systems were developed for the production of cephalosporins with Streptomyces clavuligerus and Cephalosporium acremonium. S. clavuligerus NRRL 3585 was grown on moistened barley under optimum solid state fermentation conditions for 7 days; approximately 300 micrograms cephalosporins per g substrate were extracted from the kernels. C. acremonium C-10 produced approximately 950 micrograms cephalosporin C per g substrate after 10 days of solid state fermentation.
开发了固态发酵系统，用于用棒状链霉菌和顶头孢霉生产头孢菌素。将棒状链霉菌NRRL 3585在湿润的大麦上于最佳固态发酵条件下培养7天；从谷粒中提取出每克底物约300微克头孢菌素。顶头孢霉C-10在固态发酵10天后，每克底物产生约950微克头孢菌素C。
