庆大霉素经气管内给药于大鼠后的药代动力学
Pharmacokinetics of gentamicin administered intratracheally to rats.
作者信息
Trnovec T, Navarová J, Kettner M, Gregusková M, Bezek S, Gajdosík A, Kyselová A
出版信息
Antimicrob Agents Chemother. 1978 Aug;14(2):165-7. doi: 10.1128/AAC.14.2.165.
Abstract
The pharmacokinetics of intratracheally instilled and intravenously injected gentamicin were compared in the rat and analyzed by a one-compartment open model. The maximum concentration of gentamicin in plasma occurred within 10 min after intratracheal instillation. Considerable amounts of gentamicin were absorbed from lungs after intratracheal instillation, as shown by its concentrations in plasma and elimination in urine. The data suggest that the absorption of gentamicin from the pulmonary system would be sufficient to maintain therapeutic levels of this agent in plasma.
摘要
在大鼠体内比较了气管内滴注和静脉注射庆大霉素的药代动力学，并采用一室开放模型进行分析。气管内滴注后10分钟内血浆中庆大霉素浓度达到最高。气管内滴注后，肺部吸收了大量庆大霉素，血浆中的浓度及尿中的排泄情况均表明了这一点。数据表明，庆大霉素从肺系统的吸收足以维持该药物在血浆中的治疗水平。
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Persistence of sisomicin and gentamicin in renal cortex and medulla compared with other organs and serum of rats.与大鼠的其他器官和血清相比，西索米星和庆大霉素在肾皮质和髓质中的存留情况。
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Schweiz Med Wochenschr. 1977 Apr 30;107(17):589-97.
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