辐射引起的庆大霉素药代动力学变化。
Radiation-induced changes in gentamicin pharmacokinetics.
作者信息
Trnovec T, Bezek S, Navarová J, Gregusková M, Kettner M, Laginová V
出版信息
Experientia. 1980 Sep 15;36(9):1098-9. doi: 10.1007/BF01965991.
PMID:7418850
Abstract
Decreased clearance of i.v. or intratracheally administered gentamicin was observed in rats following single whole-body irradiation. 6 Gy 60Co. reaching its lowest rate on the 7th post-irradiation day. Simultaneously the absorption rate of gentamicin from the lungs was found to be increased.
摘要
在单次全身照射后的大鼠中，观察到静脉注射或气管内给予庆大霉素后的清除率降低。60钴6戈瑞，在照射后第7天达到最低速率。同时发现庆大霉素从肺部的吸收率增加。
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