Williams P P
Antimicrob Agents Chemother. 1978 Aug;14(2):210-3. doi: 10.1128/AAC.14.2.210.
By a tube dilution assay technique, 51 antimicrobial agents were singly tested against 9 strains of Mycoplasma hyopneumoniae and 1 strain of M. hyorhinis for the purpose of obtaining information useful for selecting an agent for testing in vivo against porcine mycoplasmal pneumonia. Based on determining minimal inhibitory concentrations and chemically grouping the agents into nine classes, all M. hyopneumoniae strains were found resistant to penicillins and peptides and susceptible to sulfonamides and tetracyclines, and, in other classes, were either susceptible or resistant depending on the particular agent being tested. Strains were susceptible to the same 33 of the 51 agents. Minimal inhibitory concentrations ranged from 0.06 to 9.20 mug/ml. M. hyorhinis was susceptible to 19 of the 33 agents that M. hyopneumoniae was susceptible to. Minimal inhibitory concentrations ranged from 0.03 to 8.10 mug/ml. All strains of M. hyopneumoniae differed from M. hyorhinis in that they were susceptible to cephaloglycin and nitrofurazone.
采用试管稀释测定技术，对51种抗菌剂分别针对9株猪肺炎支原体和1株猪鼻支原体进行了测试，目的是获取有助于选择用于体内测试猪支原体肺炎的药物的有用信息。基于测定最低抑菌浓度并将这些药物化学分类为九类，发现所有猪肺炎支原体菌株对青霉素和肽类耐药，对磺胺类和四环素类敏感，而在其他类别中，根据所测试的特定药物，要么敏感要么耐药。这些菌株对51种药物中的33种表现出相同的敏感性。最低抑菌浓度范围为0.06至9.20微克/毫升。猪鼻支原体对猪肺炎支原体敏感的33种药物中的19种敏感。最低抑菌浓度范围为0.03至8.10微克/毫升。所有猪肺炎支原体菌株与猪鼻支原体的不同之处在于它们对头孢氨苄和呋喃西林敏感。
