Reimann J, Diamantstein T
Immunobiology. 1981;159(3):228-34. doi: 10.1016/S0171-2985(81)80081-2.
The intravenous injection of polyclonally activated lymphoblasts elicited a proliferative T cell reaction in the spleens of syngeneic recipient mice. In the non-fractionated cell populations obtained from these spleens 6 days after lymphoblast transfer, the LPS-induced proliferation and differentiation of B cells in vitro was suppressed. This suppressive effect was mediated by T cells, as i) treatment with anti-Thy-1 antiserum plus complement restored responsiveness of B cells to LPS in the spleen cell population that had responded in vivo to a syngeneic lymphoblast graft, and ii) the responsiveness of B cells to LPS was not impaired in non-fractionated spleen cell populations of nu/nu mice injected with syngeneic lymphoblasts. The relationship of this nonspecific T suppressor cell activity to the previously described non-specific T helper cell activity for B cell activation is discussed.
静脉注射多克隆激活的淋巴母细胞可在同基因受体小鼠脾脏中引发增殖性T细胞反应。在淋巴母细胞转移6天后从这些脾脏获得的未分级细胞群体中，体外LPS诱导的B细胞增殖和分化受到抑制。这种抑制作用由T细胞介导，因为：i）用抗Thy-1抗血清加补体处理可恢复在体内对同基因淋巴母细胞移植有反应的脾细胞群体中B细胞对LPS的反应性；ii）注射同基因淋巴母细胞的裸鼠未分级脾细胞群体中B细胞对LPS的反应性未受损。本文讨论了这种非特异性T抑制细胞活性与先前描述的B细胞激活的非特异性T辅助细胞活性之间的关系。
