免疫网络。处于各种稳态时产生抗体和独特型的B细胞克隆的频率。
Immune networks. Frequencies of antibody- and idiotype-producing B cell clones in various steady states.
作者信息
Bernabé R R, Coutinho A, Martinez-A C, Cazenave P A
出版信息
J Exp Med. 1981 Aug 1;154(2):552-6. doi: 10.1084/jem.154.2.552.
Abstract
In limiting dilution analysis, the absolute frequencies of lipopolysaccharide-reactive B cell precursors producing anti-trinitrophenyl antibodies or the MOPC460 idiotype were studied in BALB/c mice, either normal, or immunized with antigen (Ab1), the idiotype (Ab2), or a monoclonal anti-idiotype antibody (Ab3). Anti-idiotype immunity results in the suppression of the B cell precursors for the relevant idiotype, and anti-(anti-idiotype) immunity leads to a 10-fold increase in precursor B cell frequencies, with a comparatively lower increase in antibody-producing precursors. The findings can only be explained by variations in the composition of the B cell compartment in the various immune states.
摘要
在有限稀释分析中，研究了正常或用抗原（Ab1）、独特型（Ab2）或单克隆抗独特型抗体（Ab3）免疫的BALB/c小鼠中产生抗三硝基苯抗体或MOPC460独特型的脂多糖反应性B细胞前体的绝对频率。抗独特型免疫导致相关独特型的B细胞前体受到抑制，而抗（抗独特型）免疫导致前体B细胞频率增加10倍，产生抗体的前体增加相对较少。这些发现只能通过不同免疫状态下B细胞区室组成的变化来解释。
相似文献
1
Immune networks. Frequencies of antibody- and idiotype-producing B cell clones in various steady states.免疫网络。处于各种稳态时产生抗体和独特型的B细胞克隆的频率。
J Exp Med. 1981 Aug 1;154(2):552-6. doi: 10.1084/jem.154.2.552.
2
Idiotype-anti-idiotype regulation. I. Immunization with a levan-binding myeloma protein leads to the appearance of auto-anti-(anti-idiotype) antibodies and to the activation of silent clones.独特型-抗独特型调节。I. 用结合果聚糖的骨髓瘤蛋白进行免疫会导致自身抗（抗独特型）抗体的出现以及沉默克隆的激活。
J Exp Med. 1981 Apr 1;153(4):951-67. doi: 10.1084/jem.153.4.951.
3
Suppression of a "recurrent" idiotype results in profound alterations of the whole B-cell compartment.“复发”独特型的抑制会导致整个B细胞区室发生深刻改变。
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6416-20. doi: 10.1073/pnas.78.10.6416.
4
The immune response to bacterial dextrans. VI. No correlation between the frequency of cells expressing a major anti-dextran idiotype and the idiotype profiles of specific antibody responses.对细菌葡聚糖的免疫反应。VI. 表达主要抗葡聚糖独特型的细胞频率与特异性抗体反应的独特型谱之间无相关性。
Scand J Immunol. 1989 Apr;29(4):427-37. doi: 10.1111/j.1365-3083.1989.tb01142.x.
5
Assessment of a functional role of auto-anti-idiotypes in idiotype dominance.自身抗独特型在独特型优势中的功能作用评估。
Eur J Immunol. 1995 Mar;25(3):830-7. doi: 10.1002/eji.1830250330.
6
Absolute frequencies of lipopolysaccharide-reactive B cells producing A5A idiotype in unprimed, streptococcal A carbohydrate-primed, anti-A5A idiotype-sensitized and anti-A5A idiotype-suppressed A/J mice.未致敏、A 群链球菌碳水化合物致敏、抗 A5A 独特型致敏及抗 A5A 独特型抑制的 A/J 小鼠中产生 A5A 独特型的脂多糖反应性 B 细胞的绝对频率。
J Exp Med. 1977 Nov 1;146(5):1436-49. doi: 10.1084/jem.146.5.1436.
7
Induction and regulation of silent idiotype clones.沉默独特型克隆的诱导与调控。
Eur J Immunol. 1981 May;11(5):393-8. doi: 10.1002/eji.1830110509.
8
Regulation of the anti-trinitrophenyl response by anti-idiotype antibodies.抗独特型抗体对抗三硝基苯基反应的调节
Ann N Y Acad Sci. 1983;418:26-30. doi: 10.1111/j.1749-6632.1983.tb18051.x.
9
A comparison of the anti-idiotypic responses generated by antibodies to a protein and a hapten: a common interspecies idiotype on antibodies against human albumin induces an idiotypic network in rabbits.针对蛋白质和半抗原的抗体所产生的抗独特型反应的比较：抗人白蛋白抗体上的一种常见种间独特型在兔体内诱导出独特型网络。
Immunol Cell Biol. 1996 Feb;74(1):72-80. doi: 10.1038/icb.1996.10.
10
Idiotype-anti-idiotype interactions and the control of the anti-beta (2 leads to 6) polyfructosan response in the mouse: specificity and idiotypy of anti-ABPC48 anti-idiotypic monoclonal antibodies.独特型-抗独特型相互作用与小鼠抗β（2至6）多聚果糖反应的调控：抗ABPC48抗独特型单克隆抗体的特异性与独特型
Eur J Immunol. 1981 Sep;11(9):678-85. doi: 10.1002/eji.1830110903.
引用本文的文献
1
Mitogen-reactive B cell subpopulations selectively express different sets of V regions.有丝分裂原反应性B细胞亚群选择性表达不同的V区集。
J Exp Med. 1982 Jul 1;156(1):181-90. doi: 10.1084/jem.156.1.181.
2
The B cell repertoire revealed by major histocompatibility complex-specific helper T cells. I. Frequencies of a genetically defined V region marker among mitogen- and T helper cell-reactive B lymphocytes in normal and immunized mice.主要组织相容性复合体特异性辅助性T细胞所揭示的B细胞库。I. 正常和免疫小鼠中丝裂原及T辅助细胞反应性B淋巴细胞内一个基因定义的V区标记的频率。
J Exp Med. 1984 Apr 1;159(4):1253-69. doi: 10.1084/jem.159.4.1253.
3
Variable region sequences of murine IgM anti-IgG monoclonal autoantibodies (rheumatoid factors). A structural explanation for the high frequency of IgM anti-IgG B cells.小鼠IgM抗IgG单克隆自身抗体（类风湿因子）的可变区序列。对IgM抗IgG B细胞高频率的结构解释。
J Exp Med. 1986 Aug 1;164(2):407-27. doi: 10.1084/jem.164.2.407.
4
Turning (Ir gene) low responders into high responders by antibody manipulation of the developing immune system.通过对发育中的免疫系统进行抗体调控，将（Ir基因）低反应者转变为高反应者。
Proc Natl Acad Sci U S A. 1987 Jun;84(11):3812-6. doi: 10.1073/pnas.84.11.3812.
5
Memory but no suppression in low-dimensional symmetric idiotypic networks.低维对称独特型网络中的记忆但无抑制
Bull Math Biol. 1989;51(2):223-46. doi: 10.1007/BF02458444.
6
Unreasonable implications of reasonable idiotypic network assumptions.合理的独特型网络假设的不合理推论。
Bull Math Biol. 1989;51(3):381-408. doi: 10.1007/BF02460115.
本文引用的文献
1
Towards a network theory of the immune system.迈向免疫系统的网络理论。
Ann Immunol (Paris). 1974 Jan;125C(1-2):373-89.
2
Antibodies to idiotypes of isologous immunoglobulins.同种免疫球蛋白独特型的抗体。
J Exp Med. 1975 Jun 1;141(6):1411-26. doi: 10.1084/jem.141.6.1411.
3
A plaque assay for all cells secreting Ig of a given type or class.针对所有分泌特定类型或类别的免疫球蛋白的细胞进行的噬斑测定。
Eur J Immunol. 1976 Aug;6(8):588-90. doi: 10.1002/eji.1830060812.
4
Absolute frequencies of lipopolysaccharide-reactive B cells producing A5A idiotype in unprimed, streptococcal A carbohydrate-primed, anti-A5A idiotype-sensitized and anti-A5A idiotype-suppressed A/J mice.未致敏、A 群链球菌碳水化合物致敏、抗 A5A 独特型致敏及抗 A5A 独特型抑制的 A/J 小鼠中产生 A5A 独特型的脂多糖反应性 B 细胞的绝对频率。
J Exp Med. 1977 Nov 1;146(5):1436-49. doi: 10.1084/jem.146.5.1436.
5
Clonal growth and maturation to immunoglobulin secretion in vitro of every growth-inducible B lymphocyte.每一个生长可诱导的B淋巴细胞在体外的克隆生长及向免疫球蛋白分泌的成熟过程。
Cell. 1977 Jan;10(1):27-34. doi: 10.1016/0092-8674(77)90136-2.
6
Regulation of anti-TNP response by antiidiotypic and anti-(antiidiotypic) antibodies.抗独特型抗体和抗（抗独特型）抗体对抗-TNP反应的调节。
Ann Immunol (Paris). 1979 Mar-Apr;130(2):303-9.
7
Expression and induction of MOPC-460 idiotopes in different strains of mice.MOPC-460独特型表位在不同品系小鼠中的表达与诱导
Ann Immunol (Paris). 1979 Mar-Apr;130(2):293-302.
8
Idiotypic regulation of the immune system by the induction of antibodies against anti-idiotypic antibodies.通过诱导抗独特型抗体的抗体来实现免疫系统的独特型调节。
Proc Natl Acad Sci U S A. 1977 Nov;74(11):5126-30. doi: 10.1073/pnas.74.11.5126.
9
Idiotypic-anti-idiotypic regulation of antibody synthesis in rabbits.兔体内抗体合成的独特型-抗独特型调节
Proc Natl Acad Sci U S A. 1977 Nov;74(11):5122-5. doi: 10.1073/pnas.74.11.5122.
10
Cellular basis of regulation of expression of idiotype. II. Immunity to anti-MOPC-460 idiotype antibodies increases the level of anti-trinitrophenyl antibodies bearing 460 idiotypes.独特型表达调控的细胞基础。II. 对抗MOPC - 460独特型抗体的免疫反应可提高带有460独特型的抗三硝基苯抗体的水平。
J Exp Med. 1979 Apr 1;149(4):815-23. doi: 10.1084/jem.149.4.815.
Zotero 插件