兔体内抗体合成的独特型-抗独特型调节
Idiotypic-anti-idiotypic regulation of antibody synthesis in rabbits.
作者信息
Cazenave P A
出版信息
Proc Natl Acad Sci U S A. 1977 Nov;74(11):5122-5. doi: 10.1073/pnas.74.11.5122.
Abstract
Anti-ribonuclease antibodies (Ab1) of one rabbit were used to prepare in two other rabbits anti-idiotypic antibodies (Ab2) against them. Anti-idiotypic antibodies (Ab3) were prepared against Ab2 of one rabbit in two other rabbits that had the same phenotype as the former three for the allotypic a and b systems. After a rest period of 4 months, the latter two rabbits were immunized against ribonuclease. The antibodies produced (Ab1') crossreacted with the two anti-idiotypic sera (Ab2) against Ab1, showing an idiotypic similarity between anti-ribonuclease Ab1' and anti-ribonuclease Ab1. No such crossreaction was observed between the anti-idiotypic sera (Ab2) against Ab1 and any of the 12 unrelated antisera against ribonuclease that were tested. These results suggest (i) that rabbits, at least with the same allotypes, possess a closely related idiotypic repertoire; and (ii) that the immune system is a network of variable (V)-domains.
摘要
用一只兔子的抗核糖核酸酶抗体（Ab1）在另外两只兔子体内制备针对它们的抗独特型抗体（Ab2）。在另外两只与前三只兔子在同种异型a和b系统中具有相同表型的兔子体内，针对其中一只兔子的Ab2制备抗独特型抗体（Ab3）。在休息4个月后，对后两只兔子进行核糖核酸酶免疫。产生的抗体（Ab1'）与针对Ab1的两种抗独特型血清（Ab2）发生交叉反应，表明抗核糖核酸酶Ab1'与抗核糖核酸酶Ab1之间存在独特型相似性。在针对Ab1的抗独特型血清（Ab2）与所测试的12种无关的抗核糖核酸酶血清之间未观察到这种交叉反应。这些结果表明：（i）兔子至少在具有相同同种异型的情况下，拥有密切相关的独特型库；（ii）免疫系统是一个可变（V）结构域的网络。
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