Seifter E, Rettura G, Stratford F, Yee C, Weinzweig J, Jacobson N L, Levenson S M
JPEN J Parenter Enteral Nutr. 1981 Jul-Aug;5(4):288-94. doi: 10.1177/0148607181005004288.
We have previously reported that supplemental vitamin A ameliorates the stress response to a wide variety of noxious agents. The present study was carried out to determine how supplemental vitamin A influences the course of radiation sickness in C3H female mice subjected to 3000 R irradiation of one lower hind limb. All mice ingested a chow diet containing about 13,000 units of vitamin A/kg diet (about half as preformed vitamin A and half as beta-carotene) which supports normal growth, development, and reproduction of normal mice. One hundred fifty thousand units of vitamin A/kg chow was added for the vitamin A supplemented mice. All mice ate and drank ad libitum. The supplemental vitamin A feeding was begun either 3 days before radiation or immediately after radiation. There were no significant differences in the effects of these two regimens. The supplemental vitamin A prevented the weight loss, moderated the adrenal hypertrophy, prevented the thymic involution, and lessened the lymphopenia due to radiation. We conclude that supplemental vitamin A has both prophylactic and therapeutic benefits in radiation-induced disease.
我们之前曾报道，补充维生素A可改善对多种有害因子的应激反应。本研究旨在确定补充维生素A如何影响接受3000伦琴单侧后肢照射的C3H雌性小鼠的放射病病程。所有小鼠均食用含约13,000单位维生素A/千克日粮（约一半为预形成维生素A，一半为β-胡萝卜素）的饲料，该饲料可支持正常小鼠的生长、发育和繁殖。给补充维生素A的小鼠的饲料中添加150,000单位维生素A/千克。所有小鼠均自由进食和饮水。补充维生素A的喂养在辐射前3天或辐射后立即开始。这两种方案的效果无显著差异。补充维生素A可防止体重减轻，减轻肾上腺肥大，防止胸腺萎缩，并减轻辐射引起的淋巴细胞减少。我们得出结论，补充维生素A在辐射诱发疾病中具有预防和治疗益处。
