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血清胸腺因子作为一种辐射防护剂可促进X射线照射后的存活。

Serum thymic factor as a radioprotective agent promoting survival after X-irradiation.

作者信息

Kobayashi H, Abe H, Awaya A, Inano H, Shikita M

机构信息

Institute of Biological Science, Mitsui Pharmaceuticals, Inc., Mobara, Japan.

出版信息

Experientia. 1990 May 15;46(5):484-6. doi: 10.1007/BF01954239.

DOI:10.1007/BF01954239
PMID:2189748
Abstract

Serum thymic factor (FTS, zinc-free thymulin) protected mice from death after whole-body X-irradiation. It was significantly radioprotective even when administered after irradiation, but it was more effective when administered both before and after irradiation. The protective effect appears to be due to the enhancement of hematologic recovery in the animals.

摘要

血清胸腺因子（FTS，无锌胸腺素）可保护小鼠免受全身X线照射后的死亡。即使在照射后给药，它也具有显著的辐射防护作用，但在照射前后都给药时效果更佳。这种保护作用似乎是由于促进了动物的血液学恢复。

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Serum thymic factor as a radioprotective agent promoting survival after X-irradiation.血清胸腺因子作为一种辐射防护剂可促进X射线照射后的存活。
Experientia. 1990 May 15;46(5):484-6. doi: 10.1007/BF01954239.
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Radioprotective effects of serum thymic factor in mice.血清胸腺因子对小鼠的辐射防护作用。
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本文引用的文献

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Intensive suppression of experimental allergic encephalomyelitis (EAE) by serum thymic factor and therapeutic implication for multiple sclerosis.血清胸腺因子对实验性变态反应性脑脊髓炎的强效抑制作用及其对多发性硬化症的治疗意义
Jpn J Exp Med. 1982 Aug;52(4):213-9.
2
Contribution of zinc and other metals to the biological activity of the serum thymic factor.锌及其他金属对血清胸腺因子生物活性的作用。
Proc Natl Acad Sci U S A. 1982 Sep;79(17):5370-3. doi: 10.1073/pnas.79.17.5370.
3
Endotoxin protection and colony-forming units.
Radiat Res. 1967 Nov;32(3):367-82.
4
Thymulin.胸腺素
Methods Enzymol. 1985;116:269-79. doi: 10.1016/s0076-6879(85)16021-0.
5
Radioprotection of hemopoiesis conferred by Acanthopanax senticosus Harms (Shigoka) administered before or after irradiation.刺五加（刺五加）在照射前或照射后给予对造血功能的辐射防护作用。
Exp Hematol. 1988 Oct;16(9):801-6.
6
Use of recombinant granulocyte-macrophage colony stimulating factor in the Brazil radiation accident.重组粒细胞-巨噬细胞集落刺激因子在巴西放射事故中的应用。
Lancet. 1988 Aug 27;2(8609):471-5. doi: 10.1016/s0140-6736(88)90121-3.
7
Suppression of acute experimental allergic encephalomyelitis by synthetic serum thymic factor. Clinical, histopathological, and immunohistochemical studies.合成血清胸腺因子对急性实验性变应性脑脊髓炎的抑制作用。临床、组织病理学及免疫组织化学研究。
Acta Neuropathol. 1988;75(4):337-44. doi: 10.1007/BF00687786.
8
Modifiers of radiosensitivity.放射敏感性的调节剂。
Experientia. 1989 Jan 15;45(1):41-52. doi: 10.1007/BF01990451.
9
Cytokines in therapy of radiation injury.
Blood. 1988 Sep;72(3):1093-5.
10
Interdependence of the radioprotective effects of human recombinant interleukin 1 alpha, tumor necrosis factor alpha, granulocyte colony-stimulating factor, and murine recombinant granulocyte-macrophage colony-stimulating factor.人重组白细胞介素1α、肿瘤坏死因子α、粒细胞集落刺激因子及小鼠重组粒细胞-巨噬细胞集落刺激因子辐射防护作用的相互依赖性
J Immunol. 1988 Jan 1;140(1):108-11.