Capron J P, Lemay J L, Muir J F, Dupas J L, Lebrec D, Gineston J L
J Clin Gastroenterol. 1981 Sep;3(3):295-8. doi: 10.1097/00004836-198109000-00016.
We report a 33-year-old woman who took oral contraceptives for 8 years, and who developed gastrointestinal bleeding from esophageal varices. Celiac and mesenteric angiography demonstrated a portal vein thrombosis. Because of several episodes of dyspnea, a pulmonary angiogram was also performed, and showed partial or complete obstruction of both inferior pulmonary arteries with "pruning" of lower lobes. Despite immediate anticoagulant therapy, the patient died suddenly some days later. We believe that oral contraceptive treatment could have induced thromboembolic disease both in portal and pulmonary circulations in this patient.
我们报告一名33岁女性，她服用口服避孕药8年，因食管静脉曲张出现胃肠道出血。腹腔动脉和肠系膜血管造影显示门静脉血栓形成。由于数次出现呼吸困难，还进行了肺血管造影，结果显示双下肺动脉部分或完全阻塞，下叶呈“截断”状。尽管立即进行了抗凝治疗，但患者在数天后突然死亡。我们认为，口服避孕药治疗可能诱发了该患者门静脉和肺循环的血栓栓塞性疾病。
