对高度纯化的脾脏来源免疫抑制肽（SDIP）体液反应的进一步研究。
Further study on the humoral response of a highly-purified spleen-derived immunosuppressive peptide (SDIP).
作者信息
Duchange N, Millerioux L, Lenfant M
出版信息
Immunology. 1981 Oct;44(2):249-55.
Some biological properties of a highly-purified non-cytotoxic spleen-derived immunosuppressive peptide (SDIP) have been investigated. SDIP was shown to inhibit the primary anti-sheep red blood cell (SRBC) response at the last step of differentiation of the lymphocyte. In the present study we demonstrated that this response seemed to be T- and adherent spleen-cell dependent as no inhibition was noticed either in the response to TNP-LPS, a T-independent antigen, or in the response to SRBC in adherent spleen cell-depleted cultures. SDIP activity did not occur through an inhibition of splenocytes DNA synthesis since [3H]-thymidine ([3H]-TdR) incorporation was not modified in mitogen or allogenic stimulated cultures. Conversely, SDIP could act through a stimulation of a T-cell subset as a low specific increase of [3H]-TdR was noticed in cultured thymocytes.
对一种高度纯化的无细胞毒性的脾脏衍生免疫抑制肽（SDIP）的一些生物学特性进行了研究。结果表明，SDIP在淋巴细胞分化的最后阶段能抑制原发性抗绵羊红细胞（SRBC）反应。在本研究中，我们证明这种反应似乎依赖于T细胞和黏附性脾细胞，因为在对TNP-LPS（一种非T细胞依赖性抗原）的反应中或在去除黏附性脾细胞的培养物中对SRBC的反应中均未观察到抑制作用。SDIP的活性并非通过抑制脾细胞DNA合成产生，因为在有丝分裂原或同种异体刺激的培养物中，[3H] - 胸腺嘧啶核苷（[3H] - TdR）掺入未发生改变。相反，SDIP可能通过刺激T细胞亚群发挥作用，因为在培养的胸腺细胞中观察到[3H] - TdR有低特异性增加。
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