Steidler N E, Reade P C
J Dent Res. 1981 Dec;60(12):1977-82. doi: 10.1177/00220345810600120901.
The proliferation of bovine odontogenic epithelial (OE) and mesenchymal (OM) cells cultured in the presence of varying concentrations of epidermal growth factor (EGF) was examined. After a delay of two to three d, EGF-supplemented cultures contained significantly more cells than did controls. This effect was dose-dependent, was maximal at 10-9 g EGF/ml for OE and 10-8 g EGF/ml for OM, and was dependent on the presence of serum in the culture medium. The results suggest the possibility that EGF may play a role in the control of odontogenic cell proliferation in vivo.
研究了在不同浓度表皮生长因子（EGF）存在的情况下培养的牛牙源性上皮（OE）细胞和间充质（OM）细胞的增殖情况。在延迟两到三天后，添加EGF的培养物中的细胞明显比对照培养物中的多。这种作用呈剂量依赖性，对于OE细胞，在EGF浓度为10-9 g/ml时达到最大值，对于OM细胞，在EGF浓度为10-8 g/ml时达到最大值，并且这种作用依赖于培养基中血清的存在。结果提示EGF可能在体内牙源性细胞增殖的调控中发挥作用。
