Chernushenko E F, Shiniberov V A
Antibiotiki. 1981 Oct;26(10):743-6.
The studies with 60 guinea pigs and 111 albino mice showed that the daily use of rifampicin for a prolonged period of time in an oral dose of 30 mg/kg for the guinea pigs and 20 mg/kg for the mice had a pronounced effect on the immunological reactivity of the host. The use of rifampicin for 3 months resulted in changed in the structure of the lymphoid organs and suppression of T-lymphocytes. It had an inhibitory effect on the development of the anaphylactic shock in response to the resolution dose of the foreign serum. The preliminary treatment of the mice with rifampicin for 2 months lowered the primary and to a greater extent the secondary immune response induced by the sheep red blood cells.
对60只豚鼠和111只白化小鼠的研究表明，长时间每日给豚鼠口服30毫克/千克、给小鼠口服20毫克/千克的利福平，对宿主的免疫反应性有显著影响。使用利福平3个月会导致淋巴器官结构改变并抑制T淋巴细胞。它对因异种血清消退剂量引起的过敏性休克的发展有抑制作用。用利福平对小鼠进行2个月的预处理会降低由绵羊红细胞诱导的初次免疫反应，在更大程度上降低二次免疫反应。
