Bykova M A, Solov'ev V N, Berezhinskaia V V, Egorenko G G, Firsov A A
Antibiotiki. 1977 Jun;22(6):525-30.
The data on pharmacological study of rifampicin prepared at the All-Union Research Institute of Antibiotics are presented. It was found that by its acute toxicity the drug conformed to rifampicin manufactured by "Lepetit (Italy). When it was administered for a prolonged period of time to rats in doses equivalent to the therapeutic ones for humans, the drug had no effect on the cardiovascular system, the function of the liver and kidneys, growth and debelopment of the rats, the pictures of the peripheral blood. When rifampicin was used in doses 4--8 times higher than the therapeutic ones, it sometimes induced a decrease in the erythrocyte count and hemoglobin level, changes in the liver function, a reliable arrest of the rat growth, some changes in the liver and gastric mucosa revealed on histological examination. No allergic properties of rifampicin were observed in guinea pigs of light colour. No differences in the effect of rifampicin of the Soviet, Italian and Polish production were found.
本文介绍了全苏抗生素研究所制备的利福平的药理学研究数据。结果发现，该药物的急性毒性与意大利“莱佩蒂”公司生产的利福平相当。当以相当于人类治疗剂量的剂量长期给大鼠用药时，该药物对心血管系统、肝脏和肾脏功能、大鼠的生长发育以及外周血图像均无影响。当使用比利福平治疗剂量高4至8倍的剂量时，有时会导致红细胞计数和血红蛋白水平下降、肝功能改变、大鼠生长明显停滞，组织学检查显示肝脏和胃黏膜有一些变化。在浅色豚鼠中未观察到利福平的过敏特性。未发现苏联、意大利和波兰生产的利福平在效果上有差异。
