Devgun M S, Paterson C R, Martin B T
Enzyme. 1981;26(6):301-5. doi: 10.1159/000459198.
This paper reports a seasonal variation in alkaline phosphatase (ALP) levels in the serum, with low values occurring in summer and high in winter. These variations were found both in indoor and outdoor workers and in a group of elderly women in a long-stay ward. The seasonal change in ALP was in the opposite direction to the seasonal change in the serum levels of 25-hydroxyvitamin D. No such change was seen in the serum levels of gamma-glutamyltransferase. It is suggested that the seasonal change in plasma ALP could be due to changes in the bone isoenzyme. Serum levels of calcium remained unchanged; the change in ALP may reflect a homeostatic mechanism controlling plasma calcium, which compensates for seasonal variations in vitamin D supply.
本文报道了血清碱性磷酸酶（ALP）水平的季节性变化，夏季水平较低，冬季较高。在室内和室外工作者以及长期住院病房的一组老年女性中均发现了这些变化。ALP的季节性变化与25-羟基维生素D血清水平的季节性变化方向相反。γ-谷氨酰转移酶的血清水平未出现此类变化。有人认为血浆ALP的季节性变化可能是由于骨同工酶的变化所致。血清钙水平保持不变；ALP的变化可能反映了控制血浆钙的一种稳态机制，该机制可补偿维生素D供应的季节性变化。
