骨重塑生化参数的季节性差异。
Seasonal differences in biochemical parameters of bone remodelling.
作者信息
Douglas A S, Miller M H, Reid D M, Hutchison J D, Porter R W, Robins S P
机构信息
University Department of Medicine and Therapeutics, Medical School, Aberdeen.
出版信息
J Clin Pathol. 1996 Apr;49(4):284-9. doi: 10.1136/jcp.49.4.284.
AIMS
To compare bone remodelling parameters in late autumn and early spring in 20 post-menopausal women.
METHODS
The parameters measured were serum osteocalcin and its apparent degree of carboxylation (measured by hydroxyapatite binding), total and bone specific alkaline phosphatase and urinary bone resorption markers, (pyridinoline and deoxypyridinoline).
RESULTS
Serum osteocalcin concentrations were lower in autumn than in spring but the degree of carboxylation was similar. Total and bone specific alkaline phosphatase activities in serum were higher in autumn than in spring. These results support previous observations. However, notable and previously unreported changes in urinary bone resorption markers were observed. Pyridinoline concentrations were lower and deoxypyridinoline higher in autumn compared with spring. The ratio of pyridinoline:deoxypyridinoline was therefore very different between the seasons.
CONCLUSIONS
The results clearly demonstrate that seasonal changes in these variables of bone remodelling must be taken into consideration when designing, reporting or analysing studies of bone metabolism in vivo.
目的
比较20名绝经后女性在深秋和早春时的骨重塑参数。
方法
所测量的参数包括血清骨钙素及其表观羧化程度（通过羟基磷灰石结合法测量）、总碱性磷酸酶和骨特异性碱性磷酸酶以及尿骨吸收标志物（吡啶啉和脱氧吡啶啉）。
结果
秋季血清骨钙素浓度低于春季，但羧化程度相似。秋季血清中总碱性磷酸酶和骨特异性碱性磷酸酶活性高于春季。这些结果支持了之前的观察。然而，观察到尿骨吸收标志物有显著且此前未报告的变化。与春季相比，秋季吡啶啉浓度较低而脱氧吡啶啉较高。因此，不同季节吡啶啉与脱氧吡啶啉的比值差异很大。
结论
结果清楚地表明，在设计、报告或分析体内骨代谢研究时，必须考虑这些骨重塑变量的季节性变化。
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