Thompson C S, Mikhailidis D P, Gill D S, Jeremy J Y, Bell J L, Dandona P
Department of Chemical Pathology and Human Metabolism, Royal Free Hospital and School of Medicine, London, UK.
Lab Anim. 1989 Jan;23(1):53-8. doi: 10.1258/002367789780886966.
The effect of starvation and sampling time on plasma alkaline phosphatase activity, total plasma calcium concentration and whole blood ionized calcium concentration was determined in the rat. Starvation caused a significant fall in total and ionized calcium concentrations as well as in alkaline phosphatase activity. These changes were accompanied by a fall in whole blood pH and an increase in the anion gap and a decrease in urinary excretion of calcium. These indices were restored to normal following refeeding. There was no change in serum 25-OH vitamin D concentrations following starvation for 3 days. Alkaline phosphatase activity showed a pattern compatible with the presence of a circadian rhythm when sampling took place between 0800 and 1800 h. Total and ionized calcium concentrations did not show such a rhythm when animals were fed the present diet.
研究了饥饿和采样时间对大鼠血浆碱性磷酸酶活性、血浆总钙浓度和全血离子钙浓度的影响。饥饿导致总钙和离子钙浓度以及碱性磷酸酶活性显著下降。这些变化伴随着全血pH值下降、阴离子间隙增加和尿钙排泄减少。重新喂食后，这些指标恢复正常。饥饿3天后，血清25-羟基维生素D浓度没有变化。当在08:00至18:00之间采样时，碱性磷酸酶活性呈现出与昼夜节律相符的模式。当动物喂食当前饮食时，总钙和离子钙浓度未显示出这种节律。
