Rosen A D
Arch Neurol. 1978 Oct;35(10):638-42. doi: 10.1001/archneur.1978.00500340014003.
The clinical diagnosis of amyotrophic lateral sclerosis was identified in 668 patients who were followed up for periods up to three years. This disease was found to be more common in women than previously believed. The five-year survival for all patients was found to be 39.4%, but younger patients had a substantially better prognosis than those in whom the disease was diagnosed when over the age of 50 years. When the mode of onset was considered, the spinal form was associated with a threefold better five-year survival than the bulbar form.
668例患者被诊断为肌萎缩侧索硬化并接受了长达三年的随访。研究发现，这种疾病在女性中比之前认为的更为常见。所有患者的五年生存率为39.4%，但年轻患者的预后明显好于50岁以上确诊的患者。考虑发病方式时，脊髓型的五年生存率比延髓型高三倍。
