Tthyd，一种与Igh-1相关的新的胸腺细胞同种异体抗原。对T细胞抗原受体转换机制的启示。
Tthyd, a new thymocyte alloantigen linked to Igh-1. Implications for a switch mechanism for T cell antigen receptors.
作者信息
Owen F L, Spurll G M, Panageas E
出版信息
J Exp Med. 1982 Jan 1;155(1):52-60. doi: 10.1084/jem.155.1.52.
Abstract
Tthyd is an alloantigen coded for by a gene(s) near the immunoglobulin locus on chromosome 12 in the mouse. This T cell-specific antigen may be the third member of a family of antigen receptors on T cells encoded by a cluster of genes in the IgT-C region. This antigen is preferentially expressed on thymocytes in contrast to Tindd or Tsud that are expressed on peripheral T cells. The hypothesis that T cell receptors undergo a switch in surface isotype upon maturation is discussed.
摘要
Tthyd是一种同种异体抗原，由小鼠12号染色体上免疫球蛋白基因座附近的一个基因编码。这种T细胞特异性抗原可能是由IgT-C区域的一组基因编码的T细胞抗原受体家族的第三个成员。与在外周T细胞上表达的Tindd或Tsud不同，这种抗原优先在胸腺细胞上表达。文中讨论了T细胞受体在成熟时表面同种型发生转换的假说。
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Tthyd, a new thymocyte alloantigen linked to Igh-1. Implications for a switch mechanism for T cell antigen receptors.Tthyd，一种与Igh-1相关的新的胸腺细胞同种异体抗原。对T细胞抗原受体转换机制的启示。
J Exp Med. 1982 Jan 1;155(1):52-60. doi: 10.1084/jem.155.1.52.
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