Tpre是一种在12号染色体IgT - C区域编码的新的同种异体抗原，在裸鼠的骨髓、胎儿T细胞杂交体和胎儿胸腺中表达。
Tpre, a new alloantigen encoded in the IgT-C region of chromosome 12, is expressed on bone marrow of nude mice, fetal T cell hybrids, and fetal thymus.
作者信息
Owen F L
出版信息
J Exp Med. 1983 Feb 1;157(2):419-32. doi: 10.1084/jem.157.2.419.
Abstract
A new T cell alloantigen, Tpre, has been identified by monoclonal F.6.9.1 antibody. This antigen is encoded by a gene linked to the cluster of T cell antigens in the IgT-C region of chromosome 12 (Tthy, Tind, and Tsu). Tpre is distinct from Tthy, Tind, or Tsu because it is expressed on bone marrow cells of the AKR nustr/nustr, the thymus repopulating precursor cell in normal adult marrow, and normal fetal thymocytes. Several fetal and adult T cell hybrids express these antigens independently. Tpre and Tthy are expressed on largely overlapping cell populations in adult thymus.
摘要
一种新的T细胞同种异体抗原Tpre已通过单克隆F.6.9.1抗体得以鉴定。该抗原由一个与12号染色体IgT-C区域（Tthy、Tind和Tsu）中的T细胞抗原簇相连的基因编码。Tpre与Tthy、Tind或Tsu不同，因为它在AKR nustr/nustr的骨髓细胞、正常成年骨髓中的胸腺再填充前体细胞以及正常胎儿胸腺细胞上表达。几种胎儿和成人T细胞杂种独立表达这些抗原。Tpre和Tthy在成年胸腺中表达于大量重叠的细胞群体上。
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Tpre, a new alloantigen encoded in the IgT-C region of chromosome 12, is expressed on bone marrow of nude mice, fetal T cell hybrids, and fetal thymus.Tpre是一种在12号染色体IgT - C区域编码的新的同种异体抗原，在裸鼠的骨髓、胎儿T细胞杂交体和胎儿胸腺中表达。
J Exp Med. 1983 Feb 1;157(2):419-32. doi: 10.1084/jem.157.2.419.
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本文引用的文献
1
Abnormal development of the thymus in "nude" mice.“裸”鼠胸腺的异常发育。
J Exp Med. 1971 Sep 1;134(3 Pt 1):681-92. doi: 10.1084/jem.134.3.681.
2
Embryology of the lymphoid system.淋巴系统的胚胎学。
Prog Allergy. 1981;29:1-34.
3
4
Development of cytolytic T lymphocyte precursors in organ-cultured mouse embryonic thymus rudiments.器官培养的小鼠胚胎胸腺原基中细胞溶解性T淋巴细胞前体的发育
J Exp Med. 1982 Feb 1;155(2):617-22. doi: 10.1084/jem.155.2.617.
5
Tthyd, a new thymocyte alloantigen linked to Igh-1. Implications for a switch mechanism for T cell antigen receptors.Tthyd，一种与Igh-1相关的新的胸腺细胞同种异体抗原。对T细胞抗原受体转换机制的启示。
J Exp Med. 1982 Jan 1;155(1):52-60. doi: 10.1084/jem.155.1.52.
6
Restriction specificities, alloreactivity, and allotolerance expressed by T cells from nude mice reconstituted with H-2-compatible or -incompatible thymus grafts.用H-2相容或不相容胸腺移植重建的裸鼠T细胞所表现出的限制性特异性、同种异体反应性和同种耐受性。
J Exp Med. 1980 Feb 1;151(2):376-99. doi: 10.1084/jem.151.2.376.
7
8
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9
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