Wolcott D L, Wellisch D K, Robertson C R, Arthur R J
Psychosom Med. 1981 Dec;43(6):501-7. doi: 10.1097/00006842-198112000-00006.
The study investigated the relationships between specific demographic, psychosocial, and physiological variables and the severity of duodenal ulcer disease in a population of patients with proved duodenal ulcer. Intercorrelations between psychosocial and physiological variables were also studied. The study design was cross sectional and retrospectively assessed life change units and DUD severity during the previous 6 months in 39 male ulcer clinic outpatients. Anxiety, depression, life change units, the family environment, ABO blood type, secretor status, serum pepsinogen, and serum fasting gastrin were evaluated. A DUD severity score was calculated from self-reported ulcer pain symptoms and ulcer complications. Gastrin levels correlated significantly with three Family Environment Scale (FES) subscales, including: (a) independence, (b) achievement orientation, and (c) expressiveness. Duodenal ulcer disease severity scores correlated with Zung SDS scores, but not with state or trait anxiety, life change units, or the FES.
该研究调查了特定人口统计学、心理社会和生理变量与经证实患有十二指肠溃疡的患者群体中十二指肠溃疡疾病严重程度之间的关系。还研究了心理社会变量与生理变量之间的相互关系。该研究设计为横断面研究，回顾性评估了39名男性溃疡门诊患者在过去6个月中的生活变化单位和十二指肠溃疡疾病严重程度。评估了焦虑、抑郁、生活变化单位、家庭环境、ABO血型、分泌状态、血清胃蛋白酶原和血清空腹胃泌素。根据自我报告的溃疡疼痛症状和溃疡并发症计算出十二指肠溃疡疾病严重程度评分。胃泌素水平与三个家庭环境量表（FES）子量表显著相关，包括：（a）独立性，（b）成就取向，以及（c）表达性。十二指肠溃疡疾病严重程度评分与zung抑郁自评量表（SDS）评分相关，但与状态焦虑或特质焦虑、生活变化单位或家庭环境量表无关。
