Feldman M, Walker P, Goldschmiedt M, Cannon D
Department of Veterans Affairs, Veterans Administration Medical Center, Dallas, Texas.
Gastroenterology. 1992 Jan;102(1):175-80. doi: 10.1016/0016-5085(92)91798-9.
The role of mood state (affect) and personality on basal acid secretion and basal serum gastrin concentrations were examined in seven healthy men and eight patients with duodenal ulcer. In each subject, gastric secretion and affect were assessed simultaneously on 5 separate days. None of 10 self-reported affect variables correlated with daily fluctuations in basal acid secretion in either group. Three variables (tension, conflict, and anxiety) correlated significantly with serum gastrin fluctuations in normal subjects, but these relationships were not present in patients with ulcer, who were hypergastrinemic regardless of their affective state. The degree to which serum gastrin fluctuated was unrelated to personality, as assessed by Minnesota Multiphasic Personality Inventory. On the other hand, several Minnesota Multiphasic Personality Inventory scales correlated with the degree of variability in basal acid secretion, including scales that measured impulsivity and social isolation/alienation. These studies indicate that serum gastrin concentrations are related to affective state in normal men, that this relationship is altered in men with duodenal ulcer, and that certain personality traits, such as impulsivity and social isolation, are associated with more labile basal acid secretion rates.
研究了情绪状态（情感）和人格对7名健康男性及8名十二指肠溃疡患者基础胃酸分泌和基础血清胃泌素浓度的影响。对每位受试者，在5个不同日期同时评估其胃分泌和情感状态。两组中，10个自我报告的情感变量均与基础胃酸分泌的每日波动无相关性。在正常受试者中，3个变量（紧张、冲突和焦虑）与血清胃泌素波动显著相关，但在溃疡患者中不存在这些关系，无论其情感状态如何，溃疡患者均为高胃泌素血症。血清胃泌素波动程度与通过明尼苏达多相人格调查表评估的人格无关。另一方面，明尼苏达多相人格调查表的几个量表与基础胃酸分泌的变异性程度相关，包括测量冲动性和社会隔离/疏离感的量表。这些研究表明，正常男性血清胃泌素浓度与情感状态有关，十二指肠溃疡男性的这种关系发生改变，某些人格特质，如冲动性和社会隔离，与更不稳定的基础胃酸分泌率相关。
