急性特发性视神经炎和多发性硬化中的细胞介导免疫。

Cell-mediated immunity in acute idiopathic optic neuritis and multiple sclerosis.

作者信息

Sagar H J, Allonby I D

出版信息

Acta Neurol Scand. 1981 Jun;63(6):362-72. doi: 10.1111/j.1600-0404.1981.tb00790.x.

DOI:10.1111/j.1600-0404.1981.tb00790.x

Abstract

Lymphocyte transformation responses to phytohaemagglutinin, measles antigen and tuberculin and the absolute numbers of circulating T and SIg+ cells were determined in 16 patients with acute idiopathic optic neuritis (ON), 42 patients with multiple sclerosis (MS) and 78 healthy controls. Patients with acute ON showed impaired lymphocyte transformation responses in both autologous plasma and AB serum similar in extent to those seen in MS patients in relapse. They were not associated with a reduced total number of circulating T cells.

摘要

测定了16例急性特发性视神经炎（ON）患者、42例多发性硬化症（MS）患者和78名健康对照者对植物血凝素、麻疹抗原和结核菌素的淋巴细胞转化反应以及循环T细胞和表面免疫球蛋白阳性（SIg+）细胞的绝对数量。急性ON患者在自体血浆和AB血清中均表现出淋巴细胞转化反应受损，其程度与复发期MS患者相似。这些反应与循环T细胞总数减少无关。