Hutchinson W M, Haire M
Br Med J. 1976 Jan 10;1(6001):64-6. doi: 10.1136/bmj.1.6001.64.
Measles-virus-specific IgG was measured in the serum of 100 patients who had presented with optic neuritis (ON) during 1960-74. When reviewed 41 of them were found to have developed definite symptoms and signs of multiple sclerosis (MS), their serum containing significantly higher titres of the antibody than sera from either the rest of the patients or a group of normal healthy controls. In a few patients from whom cerebrospinal fluid (CSF) was obtained in the acute phase of ON, titres of measles IgG in the serum was higher in those in whom the antibody was detected in the CSF than the serum of patients without CSF antibody.
对1960年至1974年间出现视神经炎(ON)的100例患者的血清进行了麻疹病毒特异性IgG检测。复查时发现其中41例出现了明确的多发性硬化症(MS)症状和体征,他们血清中的抗体滴度明显高于其他患者或一组正常健康对照者的血清。在少数ON急性期获取脑脊液(CSF)的患者中,脑脊液中检测到抗体的患者血清中的麻疹IgG滴度高于未检测到脑脊液抗体的患者血清。