Burchardt K
Z Gesamte Inn Med. 1981 Nov 1;36(21):840.
87 adult patients with histologically confirmed diagnosis of Hodgkin's disease were examined to analyse the pattern of immune alterations with regard to the clinical stage and course of disease, and the response to treatment. Patients with advanced stages of the disease or with radio- or chemotherapeutically induced remission showed a decrease in total lymphocyte counts and a diminished count of T-lymphocytes. The lymphocyte transformation and the reactions in skin tests with DNCB and microbial antigens were the more disturbed the more the disease was advanced. Below a critical number of circulating T-lymphocytes measuring 500 cells per mm3 of peripheral blood an inhibition of T-cell function has been found. The authors conclude that a positive correlation between an undisturbed immune status and a good prognosis in Hodgkin's disease is highly probable.
对87例经组织学确诊为霍奇金病的成年患者进行了检查，以分析免疫改变模式与疾病临床分期、病程及治疗反应之间的关系。疾病晚期患者或经放疗或化疗诱导缓解的患者，其总淋巴细胞计数减少，T淋巴细胞计数降低。疾病进展越严重，淋巴细胞转化以及用二硝基氯苯（DNCB）和微生物抗原进行皮肤试验的反应受干扰越明显。当外周血每立方毫米循环T淋巴细胞数量低于500个这一临界值时，已发现T细胞功能受到抑制。作者得出结论，霍奇金病中免疫状态未受干扰与预后良好之间极有可能存在正相关。
