Tan C T, De Sousa M, Good R A
Cancer Treat Rep. 1982 Apr;66(4):969-75.
Laboratory tests of immunologic function were done in 96 children with Hodgkin's disease, at diagnosis and during and after treatment. Over the same period of time, 29 aged-matched control children were tested. The results presented in this report indicate that the immunology of childhood Hodgkin's disease has some features that distinguish it from the immunologic features of the disease in adults: (a) no progressive lymphopenia was found with advanced clinical stages; (b) peripheral blood T-lymphocyte counts were normal or high, and slight B lymphocytopenias were observed in children at all stages of the disease; (c) in spite of normal T-lymphocyte counts, a defective response to phytohemagglutinin stimulation was seen at diagnosis; and (d) recovery of the phytohemagglutinin response occurred with treatment and was related to modality of therapy and prognosis.
对96例霍奇金病患儿在诊断时、治疗期间及治疗后进行了免疫功能的实验室检测。在同一时期，对29名年龄匹配的对照儿童进行了检测。本报告中的结果表明，儿童霍奇金病的免疫学有一些特征，使其与成人该疾病的免疫学特征有所区别：(a) 临床晚期未发现进行性淋巴细胞减少；(b) 外周血T淋巴细胞计数正常或升高，且在疾病各阶段的儿童中均观察到轻度B淋巴细胞减少；(c) 尽管T淋巴细胞计数正常，但在诊断时对植物血凝素刺激的反应存在缺陷；(d) 植物血凝素反应在治疗后恢复，且与治疗方式和预后相关。
