Eastwood G L, Quimby G F
Gastroenterology. 1982 May;82(5 Pt 1):852-6.
We studied the effect of chronic aspirin ingestion on gastroduodenal epithelial proliferation by feeding rats aspirin in the drinking water. A control group of rats received plain water. At the end of 4 wk, [3H]-thymidine was given intravenously to label proliferating cells, and the rats were killed 1 h later. Sections of fundus, antrum, and proximal duodenum were processed for light autoradiography. We found that chronic aspirin ingestion stimulated epithelial proliferation in fundic mucosa but had no effect in the antrum. In the duodenum, aspirin increased proliferation in the lowest four crypt-cell positions, which most likely indicates an increase in stem-cell production. None of the tissues contained evidence of inflammation or ulceration. The proliferative effects of aspirin may help explain the previously observed phenomenon of mucosal adaptation in the rat after repeated exposure to aspirin. Further, if human gastroduodenal epithelium responds in a similar manner to chronic aspirin exposure, the effects on proliferation may explain in part the distribution of aspirin-associated ulcers.
我们通过在大鼠饮用水中添加阿司匹林来研究长期摄入阿司匹林对胃十二指肠上皮细胞增殖的影响。一组对照大鼠饮用普通水。在4周结束时，静脉注射[3H] - 胸腺嘧啶核苷以标记增殖细胞，1小时后处死大鼠。对胃底、胃窦和十二指肠近端切片进行光镜放射自显影处理。我们发现，长期摄入阿司匹林会刺激胃底黏膜上皮细胞增殖，但对胃窦没有影响。在十二指肠中，阿司匹林增加了最底部四个隐窝细胞位置的细胞增殖，这很可能表明干细胞产生增加。所有组织均未发现炎症或溃疡迹象。阿司匹林的增殖作用可能有助于解释先前观察到的大鼠反复接触阿司匹林后黏膜适应性现象。此外，如果人类胃十二指肠上皮细胞对长期接触阿司匹林有类似反应，那么其对增殖的影响可能部分解释了阿司匹林相关溃疡的分布情况。
