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Long-term infusion of L-5-hydroxytryptophan increases brain serotonin turnover and decreases blood pressure in normotensive rats.

作者信息

Echizen H, Freed C R

出版信息

J Pharmacol Exp Ther. 1982 Mar;220(3):579-84.

PMID:6977639
Abstract
摘要

相似文献

1
Long-term infusion of L-5-hydroxytryptophan increases brain serotonin turnover and decreases blood pressure in normotensive rats.长期输注L-5-羟色氨酸可增加正常血压大鼠的脑血清素周转率并降低血压。
J Pharmacol Exp Ther. 1982 Mar;220(3):579-84.
2
Effects of L-tryptophan on blood pressure in normotensive and hypertensive rats.L-色氨酸对正常血压和高血压大鼠血压的影响。
J Pharmacol Exp Ther. 1984 Aug;230(2):324-9.
3
Comparison of L-5-hydroxytryptophan and L-5-hydroxytryptophan inosinate as agents for increasing brain serotonin formation in rats.L-5-羟色氨酸与L-5-羟色氨酸肌苷酸作为增加大鼠脑内5-羟色胺生成剂的比较。
Res Commun Chem Pathol Pharmacol. 1992 Apr;76(1):121-4.
4
Functional aspects of 5-hydroxytryptamine turnover in the central nervous system.中枢神经系统中5-羟色胺代谢的功能方面
Acta Physiol Scand Suppl. 1974;403:1-56.
5
The role of brain serotonin in the mechanism of the central action of reserpine.脑血清素在利血平中枢作用机制中的作用。
J Pharmacol Exp Ther. 1966 May;152(2):340-9.
6
[Action of LSD-25 on the serontoninergic system of the rat brain modified by administration of 5-hydroxytryptophan].[5-羟色氨酸给药对大鼠脑血清素能系统的影响下LSD-25的作用]
Minerva Psichiatr. 1981 Jul-Sep;22(3):163-4.
7
Monoamines and the regulation of vigilance and sleep.
Med Biol. 1974 Jun;52(3):193-9.
8
Studies on DL-5-hydroxytryptophan-induced hyperactivity in mice.DL-5-羟色氨酸诱导小鼠多动的研究。
Adv Biochem Psychopharmacol. 1974;10:213-7.
9
Drug-induced changes of 5-hydroxyindoles in central nervous system in the rats.药物诱导大鼠中枢神经系统中5-羟色胺的变化。
Acta Med Iugosl. 1973;27(3):261-9.
10
Simultaneous measurement of 5-hydroxytryptophan and L-dihydroxyphenylalanine by high-performance liquid chromatography with electrochemical detection. Measurement of serotonin and catecholamine turnover in discrete brain regions.采用高效液相色谱-电化学检测法同时测定5-羟色氨酸和L-二羟基苯丙氨酸。测定离散脑区中血清素和儿茶酚胺的周转率。
J Chromatogr. 1982 Mar 12;228:123-30. doi: 10.1016/s0378-4347(00)80425-9.

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5-Hydroxytryptamine may be a viable treatment option for hypertension resistant to diuretic treatment.5-羟色胺可能是治疗对利尿剂治疗耐药的高血压的一种可行选择。
Am J Physiol Heart Circ Physiol. 2025 Oct 1;329(4):H838-H843. doi: 10.1152/ajpheart.00520.2025. Epub 2025 Aug 20.
2
5-HTP inhibits eosinophilia via intracellular endothelial 5-HTRs; SNPs in 5-HTRs associate with asthmatic lung function.5-羟色胺通过细胞内内皮5-羟色胺受体抑制嗜酸性粒细胞增多;5-羟色胺受体中的单核苷酸多态性与哮喘肺功能相关。
Front Allergy. 2024 May 23;5:1385168. doi: 10.3389/falgy.2024.1385168. eCollection 2024.
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β-arrestin biased signaling is not involved in the hypotensive actions of 5-HT receptor stimulation: use of Serodolin.
β-arrestin 偏向信号传导不参与 5-HT 受体刺激的降压作用:使用 Serodolin。
Pharmacol Res. 2024 Jan;199:107047. doi: 10.1016/j.phrs.2023.107047. Epub 2023 Dec 28.
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5-HT7 Receptor Restrains 5-HT-induced 5-HT2A Mediated Contraction in the Isolated Abdominal Vena Cava.5-HT7 受体抑制 5-HT 诱导的 5-HT2A 介导的离体腹静脉收缩。
J Cardiovasc Pharmacol. 2021 Aug 1;78(2):319-327. doi: 10.1097/FJC.0000000000001057.
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5-HT does not lower blood pressure in the 5-HT knockout rat.5-HT 不会降低 5-HT 敲除大鼠的血压。
Physiol Genomics. 2019 Jul 1;51(7):302-310. doi: 10.1152/physiolgenomics.00031.2019. Epub 2019 May 24.
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5-HT causes splanchnic venodilation.5-羟色胺引起内脏静脉扩张。
Am J Physiol Heart Circ Physiol. 2017 Sep 1;313(3):H676-H686. doi: 10.1152/ajpheart.00165.2017. Epub 2017 Jun 16.
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Oh, the places you'll go! My many colored serotonin (apologies to Dr. Seuss).哦,你要去的地方!我多彩的血清素(向苏斯博士致歉)。
Am J Physiol Heart Circ Physiol. 2016 Nov 1;311(5):H1225-H1233. doi: 10.1152/ajpheart.00538.2016. Epub 2016 Sep 23.
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Serotonin and blood pressure regulation.血清素与血压调节。
Pharmacol Rev. 2012 Apr;64(2):359-88. doi: 10.1124/pr.111.004697. Epub 2012 Mar 8.
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5-hydroxtryptamine receptors in systemic hypertension: an arterial focus.5-羟色胺受体与系统性高血压:动脉焦点
Cardiovasc Ther. 2011 Feb;29(1):54-67. doi: 10.1111/j.1755-5922.2010.00173.x.
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Effects of LM 5008, a selective inhibitor of 5-hydroxytryptamine uptake, on blood pressure and responses to sympathomimetic amines.5-羟色胺摄取选择性抑制剂LM 5008对血压及对拟交感胺反应的影响。
Br J Pharmacol. 1983 Aug;79(4):915-22. doi: 10.1111/j.1476-5381.1983.tb10536.x.