• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

采用高效液相色谱-电化学检测法同时测定5-羟色氨酸和L-二羟基苯丙氨酸。测定离散脑区中血清素和儿茶酚胺的周转率。

Simultaneous measurement of 5-hydroxytryptophan and L-dihydroxyphenylalanine by high-performance liquid chromatography with electrochemical detection. Measurement of serotonin and catecholamine turnover in discrete brain regions.

作者信息

Shum A, Sole M J, Van Loon G R

出版信息

J Chromatogr. 1982 Mar 12;228:123-30. doi: 10.1016/s0378-4347(00)80425-9.

DOI:10.1016/s0378-4347(00)80425-9
PMID:6978886
Abstract

A sensitive method, using reversed-phase high-performance liquid chromatography with electrochemical detection, which allows the measurement of both 5-hydroxytryptophan and L-dihydroxyphenylalanine is described. This method, used in conjunction with the administration in vivo of an L-aromatic amino acid decarboxylase inhibitor, allows the simultaneous measurement of serotonin and catecholamine synthesis rates in small discrete brain regions.

摘要

描述了一种灵敏的方法，该方法采用反相高效液相色谱法并结合电化学检测，可同时测定5-羟色氨酸和L-二羟基苯丙氨酸。此方法与体内给予L-芳香族氨基酸脱羧酶抑制剂相结合，能够同时测定小的离散脑区中5-羟色胺和儿茶酚胺的合成速率。

相似文献

1
Simultaneous measurement of 5-hydroxytryptophan and L-dihydroxyphenylalanine by high-performance liquid chromatography with electrochemical detection. Measurement of serotonin and catecholamine turnover in discrete brain regions.采用高效液相色谱-电化学检测法同时测定5-羟色氨酸和L-二羟基苯丙氨酸。测定离散脑区中血清素和儿茶酚胺的周转率。
J Chromatogr. 1982 Mar 12;228:123-30. doi: 10.1016/s0378-4347(00)80425-9.
2
Effect of chronic protein ingestion on tyrosine and tryptophan levels and catecholamine and serotonin synthesis in rat brain.慢性蛋白质摄入对大鼠脑中天冬氨酸、色氨酸水平及儿茶酚胺、5-羟色胺合成的影响。
Nutr Neurosci. 2011 Nov;14(6):260-7. doi: 10.1179/1476830511Y.0000000019.
3
High-performance liquid chromatographic procedure for the simultaneous determination of aromatic L-amino acid decarboxylase activity towards 3,4-dihydroxyphenylalanine and 5-hydroxytryptophan.
J Chromatogr. 1991 Jul 5;567(2):381-8. doi: 10.1016/0378-4347(91)80144-2.
4
Simultaneous determination of 5-hydroxytryptophan and 3,4-dihydroxyphenylalanine in rat brain by HPLC with electrochemical detection following electrical stimulation of the dorsal raphe nucleus.
J Neurochem. 1985 Jan;44(1):128-33. doi: 10.1111/j.1471-4159.1985.tb07121.x.
5
Simultaneous determination of femtomole quantities of 5-hydroxytryptophan, serotonin and 5-hydroxyindoleacetic acid in brain using HPLC with electrochemical detection.采用高效液相色谱-电化学检测法同时测定脑中飞摩尔量的5-羟色氨酸、血清素和5-羟吲哚乙酸。
Eur J Pharmacol. 1981 Jan 29;69(3):347-52. doi: 10.1016/0014-2999(81)90481-7.
6
The action L-dopa on sexual behaviour of male rats.左旋多巴对雄性大鼠性行为的作用。
Brain Res. 1973 Jun 15;55(2):383-9. doi: 10.1016/0006-8993(73)90303-x.
7
Estimation of the rate of tryptophan hydroxylation in vivo: a sensitive microassay in discrete rat brain nuclei.体内色氨酸羟化速率的测定：一种用于离散大鼠脑细胞核的灵敏微量测定法。
J Neurochem. 1980 Apr;34(4):933-40. doi: 10.1111/j.1471-4159.1980.tb09668.x.
8
Turnover of central biogenic amines in one-kidney, one-clip renal hypertensive rats.单肾单夹肾性高血压大鼠中枢生物胺的更新
Neurosci Lett. 1987 Mar 31;75(2):223-8. doi: 10.1016/0304-3940(87)90301-6.
9
Simultaneous determination of 5-hydroxytryptamine, its amino acid precursors and acid metabolite in discrete brain regions by high-performance liquid chromatography with fluorescence detection.采用高效液相色谱-荧光检测法同时测定离散脑区中的5-羟色胺、其氨基酸前体和酸性代谢物。
J Chromatogr. 1983 Jun 10;275(1):1-9. doi: 10.1016/s0378-4347(00)84338-8.
10
Serotonin turnover in individual brain nuclei: evaluation of three methods using liquid chromatography with electrochemical detection.单个脑核中的血清素周转率：使用液相色谱-电化学检测法对三种方法的评估
Life Sci. 1982 Aug 9;31(6):589-95. doi: 10.1016/0024-3205(82)90489-1.

引用本文的文献

1
Neurochemical, histological, and behavioral profiling of the acute, sub-acute, and chronic MPTP mouse model of Parkinson's disease.急性、亚急性和慢性 MPTP 帕金森病小鼠模型的神经化学、组织学和行为特征分析。
J Neurochem. 2023 Jan;164(2):121-142. doi: 10.1111/jnc.15699. Epub 2022 Nov 9.
2
Central dopamine receptor agonist and antagonist actions of the enantiomers of 3-PPP.3-PPP对映体的中枢多巴胺受体激动剂和拮抗剂作用。
Psychopharmacology (Berl). 1983;81(2):89-99. doi: 10.1007/BF00428999.
3
A homologous series of N-alkylated cis-(+)-(1 S, 2 R)-5-methoxy-1-methyl-2-aminotetralins: central dopamine receptor antagonists showing profiles ranging from classical antagonism to selectivity for autoreceptors.
一系列N-烷基化的顺式-(+)-(1S,2R)-5-甲氧基-1-甲基-2-氨基四氢萘：中枢多巴胺受体拮抗剂，其作用谱从经典拮抗作用到对自身受体的选择性。
J Neural Transm. 1986;65(1):29-38. doi: 10.1007/BF01249609.
4
Sub-chronic administration of (-)-3-PPP and central dopamine receptor sensitivity changes.(-)-3-PPP的亚慢性给药与中枢多巴胺受体敏感性变化
J Neural Transm. 1985;64(3-4):187-98. doi: 10.1007/BF01256466.
5
Development of dopamine autoreceptors in the postnatal rat brain.
J Neural Transm. 1985;62(1-2):53-63. doi: 10.1007/BF01260415.
6
Central dopaminergic properties of HW-165 and its enantiomers; trans-octahydrobenzo(f)quinoline congeners of 3-PPP.HW-165及其对映体的中枢多巴胺能特性；3-PPP的反式八氢苯并(f)喹啉同系物
Naunyn Schmiedebergs Arch Pharmacol. 1986 Jul;333(3):205-18. doi: 10.1007/BF00512931.
7
(+)-UH 232 and (+)-UH 242: novel stereoselective dopamine receptor antagonists with preferential action on autoreceptors.(+)-UH 232和(+)-UH 242：对自身受体具有优先作用的新型立体选择性多巴胺受体拮抗剂。
J Neural Transm. 1986;65(1):1-27. doi: 10.1007/BF01249608.
8
Effects of capsaicin on central monoaminergic mechanisms in the rat.辣椒素对大鼠中枢单胺能机制的影响。
J Neural Transm. 1986;66(3-4):221-42. doi: 10.1007/BF01260916.
9
GBR 13098, a selective dopamine uptake inhibitor; behavioural, biochemical and electrophysiological studies.GBR 13098，一种选择性多巴胺摄取抑制剂；行为学、生物化学及电生理学研究
Naunyn Schmiedebergs Arch Pharmacol. 1986 Dec;334(4):383-7. doi: 10.1007/BF00569374.
10
(+)-AJ 76 and (+)-UH 232: central stimulants acting as preferential dopamine autoreceptor antagonists.（+）-AJ 76和（+）-UH 232：作为优先多巴胺自身受体拮抗剂的中枢兴奋剂。
Naunyn Schmiedebergs Arch Pharmacol. 1986 Nov;334(3):234-45. doi: 10.1007/BF00508777.