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本文引用的文献

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Self-sustaining, post-DCA hypertensive cardiovascular disease.自我维持的、DCA后高血压性心血管疾病。
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Analysis of cardiovascular responses to central administration of 5-hydroxytryptamine in rats.大鼠中枢给予5-羟色胺后心血管反应的分析。
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Lowering of blood pressure by direct- and indirect-acting serotonin agonists in spontaneously hypertensive rats.直接和间接作用的5-羟色胺激动剂对自发性高血压大鼠血压的降低作用
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Long-term infusion of L-5-hydroxytryptophan increases brain serotonin turnover and decreases blood pressure in normotensive rats.长期输注L-5-羟色氨酸可增加正常血压大鼠的脑血清素周转率并降低血压。
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Treatment of hypertension with ketanserin, a new selective 5-HT2 receptor antagonist.用新型选择性5-羟色胺2（5-HT2）受体拮抗剂酮色林治疗高血压。
Br Med J (Clin Res Ed). 1982 Feb 20;284(6315):537-9. doi: 10.1136/bmj.284.6315.537.
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Review of the role of the central serotonergic neuronal system in blood pressure regulation.中枢5-羟色胺能神经元系统在血压调节中的作用综述。
Hypertension. 1980 May-Jun;2(3):243-55. doi: 10.1161/01.hyp.2.3.243.
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Assessment of Peripheral adrenergic activity and its interactions with drugs in man.人体外周肾上腺素能活性及其与药物相互作用的评估。
Eur J Clin Pharmacol. 1980 Apr;17(4):233-8. doi: 10.1007/BF00625795.
8
Relationship between the action of monoamine oxidase inhibitors on the noradrenaline uptake system and their antidepressant efficacy.单胺氧化酶抑制剂对去甲肾上腺素摄取系统的作用与其抗抑郁疗效之间的关系。
Nature. 1968 Dec 28;220(5174):1330-1. doi: 10.1038/2201330a0.
9
Effects of 5-hydroxytryptophan on arterial blood pressure, body temperature and tissue monoamines in the rat.5-羟色氨酸对大鼠动脉血压、体温及组织单胺的影响。
Acta Pharmacol Toxicol (Copenh). 1971;29(23):145-54. doi: 10.1111/j.1600-0773.1971.tb00601.x.
10
Effect of central inhibition of the 1-amino acid decarboxylase on the hypotensive action of 5-HT precursors in cats.中枢抑制氨基酸脱羧酶对猫体内5-羟色胺前体降压作用的影响。
Eur J Pharmacol. 1974 Apr;26(1):108-10. doi: 10.1016/0014-2999(74)90080-6.

5-羟色胺摄取选择性抑制剂LM 5008对血压及对拟交感胺反应的影响。

Effects of LM 5008, a selective inhibitor of 5-hydroxytryptamine uptake, on blood pressure and responses to sympathomimetic amines.

作者信息

Ashkenazi R, Finberg J P, Youdim M B

出版信息

Br J Pharmacol. 1983 Aug;79(4):915-22. doi: 10.1111/j.1476-5381.1983.tb10536.x.

DOI:10.1111/j.1476-5381.1983.tb10536.x
PMID:6652362
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2044950/
Abstract

LM 5008 (4-[2-(3-indolyl)ethyl]piperidine) (10, 20 and 50 mg kg-1) had no significant effect on pressor responses to noradrenaline or tyramine in rats anaesthetized with urethane. Desmethylimipramine (1 mg kg-1) blocked the response to tyramine but chlorimipramine (5 mg kg-1) had no significant effect on responses to noradrenaline or tyramine. In the rabbit, anaesthetized with chloralose, LM 5008 (5 mg kg-1) had no effect on pressor responses to noradrenaline, tyramine or angiotensin II, while desmethylimipramine (0.25 mg kg-1) inhibited responses to tyramine and potentiated those to noradrenaline. LM 5008 (10 mg kg-1) had no effect on resting blood pressure of conscious normotensive or DOCA-saline hypertensive rats. Tranylcypromine (5 mg kg-1) produced a fall in blood pressure in conscious normotensive and in DOCA hypertensive rats. Treatment with a combination of LM 5008 (10 mg kg-1) and tranylcypromine (5 mg kg-1) resulted in the appearance of a behavioural hyperactivity syndrome, but blood pressure was not different from that of animals treated with tranylcypromine alone. These results further demonstrate the selectivity of LM 5008 for 5-hydroxytryptamine as opposed to catecholamine uptake.

摘要

LM 5008（4-[2-(3-吲哚基)乙基]哌啶）（10、20和50毫克/千克）对用乌拉坦麻醉的大鼠对去甲肾上腺素或酪胺的升压反应无显著影响。去甲丙咪嗪（1毫克/千克）阻断了对酪胺的反应，但氯丙咪嗪（5毫克/千克）对去甲肾上腺素或酪胺的反应无显著影响。在用水合氯醛麻醉的兔子中，LM 5008（5毫克/千克）对去甲肾上腺素、酪胺或血管紧张素II的升压反应无影响，而去甲丙咪嗪（0.25毫克/千克）抑制对酪胺的反应并增强对去甲肾上腺素的反应。LM 5008（10毫克/千克）对清醒的正常血压或去氧皮质酮-盐水高血压大鼠的静息血压无影响。反苯环丙胺（5毫克/千克）使清醒的正常血压大鼠和去氧皮质酮高血压大鼠的血压下降。联合使用LM 5008（10毫克/千克）和反苯环丙胺（5毫克/千克）进行治疗导致出现行为多动综合征，但血压与单独用反苯环丙胺治疗的动物无异。这些结果进一步证明了LM 5008对5-羟色胺而非儿茶酚胺摄取的选择性。