Gordon S L, Buchanan J R, Ladda R L
J Med Genet. 1981 Dec;18(6):428-30. doi: 10.1136/jmg.18.6.428.
In a large family with 37 members with multiple exostoses, only one person has developed sarcomatous degeneration of a lesion. Our review of published reports revealed great variation in the incidence of malignancy in multiple exostoses (10 to 25%). Most studies had sampling errors leading to the apparent overstatement of risk. In large pedigrees with essentially complete ascertainment of affected subjects, the risk of malignancy is nearer 3% or less. This lower risk for malignancy may be more appropriate in counselling affected subjects.
在一个有37名成员患多发性外生骨疣的大家庭中，只有一人发生了病损的肉瘤样变性。我们对已发表报告的回顾显示，多发性外生骨疣的恶性肿瘤发生率差异很大（10%至25%）。大多数研究存在抽样误差，导致风险明显被高估。在基本完全确定受影响个体的大型家系中，恶性肿瘤的风险接近3%或更低。这种较低的恶性肿瘤风险在为受影响个体提供咨询时可能更合适。
