Wicks I P, Fleming A
Ann Rheum Dis. 1987 Apr;46(4):346-8. doi: 10.1136/ard.46.4.346.
We describe the first case of the coexistence of the hereditary connective tissue disorder multiple exostoses (HME) and an acquired connective tissue disorder manifest by the overlap of dermatomyositis (DM), scleroderma (PSS), high titre speckled pattern antinuclear antibodies, and increased antibodies to double stranded deoxyribonucleic acid (DNA). Furthermore this patient developed chondrosarcoma of the calcaneum (an unusual site for this malignancy) and massive soft tissue calcification (an unusual feature of PSS, adult DM, and systemic lupus erythematosus (SLE)).
我们描述了首例遗传性结缔组织疾病多发性外生骨疣（HME）与一种后天性结缔组织疾病并存的病例，该后天性结缔组织疾病表现为皮肌炎（DM）、硬皮病（PSS）、高滴度斑点型抗核抗体以及双链脱氧核糖核酸（DNA）抗体增加的重叠症状。此外，该患者发生了跟骨软骨肉瘤（这种恶性肿瘤的不常见发病部位）以及大量软组织钙化（PSS、成人DM和系统性红斑狼疮（SLE）的不常见特征）。
