Piérard L, Verheugt F W, Meltzer R S, Roelandt J
Acta Cardiol. 1981;36(6):455-61.
We report the M-mode and two-dimensional echocardiographic findings in a patient with familial amyloidosis. The diagnosis was made by the clinical picture and histologic evidence of amyloid in peripheral nerve biopsy. Though the patient had no clinical sign of heart failure, extensive involvement of the heart was demonstrated by echocardiography. M-mode echocardiography revealed increased right ventricular wall thickness in conjunction with symmetric increase in left ventricular wall thickness. On two-dimensional echocardiography, the entire interventricular septum and the papillary muscles were more dense than normal. These high density echoes had a "granular and sparkling" pattern. This case shows that cardiac amyloidosis can be diagnosed in the pre-clinical, asymptomatic state by M-mode and two-dimensional echocardiography. When symptomatic, confusion with constrictive pericarditis may be avoided non-invasively.
我们报告了一名家族性淀粉样变性患者的M型和二维超声心动图检查结果。诊断依据临床表现以及周围神经活检中淀粉样蛋白的组织学证据。尽管该患者没有心力衰竭的临床症状，但超声心动图显示心脏广泛受累。M型超声心动图显示右心室壁厚度增加，同时左心室壁厚度呈对称性增加。二维超声心动图显示，整个室间隔和乳头肌比正常情况更为致密。这些高密度回声呈现出“颗粒状且闪烁”的模式。该病例表明，通过M型和二维超声心动图可在临床前期、无症状状态下诊断心脏淀粉样变性。出现症状时，可通过无创检查避免与缩窄性心包炎相混淆。
