Seelig H P
Immun Infekt. 1981 Nov;9(6):223-31.
Sharp and coworkers (69) recently described a group of patients with over-lapping syndromes of lupus erythematosus, polymyositis and progressive systemic sclerosis. Since all these patients showed high titers of an antibody against RNP (ribonucleoproutein), a saline extractable constituent of nuclei, the disease was supposed to be a unique entity within the spectrum of collagen diseases (mixed connective tissue disease, overlapping syndrome). The nosological entity, however, remains to be further established since RNP-antibodies not infrequently occur in other collagenoses (LE, RA) and transition of MCTD in LE have been reported. The clinical syndromes and the serological features of MCTD are described.
夏普及其同事（69）最近描述了一组患有红斑狼疮、多发性肌炎和进行性系统性硬化重叠综合征的患者。由于所有这些患者均显示出针对核糖核蛋白（RNP，一种细胞核中可盐提取成分）的高滴度抗体，因此该疾病被认为是胶原病谱（混合性结缔组织病、重叠综合征）中的一种独特病症。然而，由于RNP抗体在其他胶原病（红斑狼疮、类风湿性关节炎）中也并非罕见，且已有混合性结缔组织病转变为红斑狼疮的报道，因此该疾病分类实体仍有待进一步确定。文中描述了混合性结缔组织病的临床综合征和血清学特征。
