Keng P C, Lee A C, Cox A B, Bergtold D S, Lett J T
Int J Radiat Biol Relat Stud Phys Chem Med. 1982 Feb;41(2):127-37. doi: 10.1080/09553008214550141.
As part of an investigation of the responses of optic and proximate tissues to heavy-ion irradiation, the lenses of New Zealand white rabbits were exposed to the Bragg plateau regions of 530 MeV/amu Ar ions and 365 MeV/amu Ne ions and also to 60Co gamma-photons. The linear energy transfers (LET infinity s) for the radiations were 90 +/- 5, 35 +/- 3, and 0.3 keV/micrometer, respectively. After irradiation, lenticular opacities were monitored through their incipient and/or clinical stages (less than or equal to 5 years) by slit-lamp biomicroscopy and scored with subjective, but well-defined, indices. Cataractogenesis, which progressed according to the model proposed by Rubin and Casarett (1968), was modified by radiation quality in the following ways. (1) The rate of development of the early (acute) stage increased with the LET infinity of the incident radiation; (2) at the intermediate (plateau) stage, the values for the relative biological effectiveness (r.b.e.) of the heavy ions were similar to those reported for proliferating cells in culture; (3) for a given intermediate level, the onset of late cataractogenesis occurred earlier the higher the LET affinity of the radiation involved. As with alopecia, the r.b.e.s for cataractogenesis varied with post-irradiation time.
作为对视神经及邻近组织对重离子辐照反应研究的一部分，将新西兰白兔的晶状体暴露于能量为530 MeV/amu的氩离子和365 MeV/amu的氖离子的布拉格峰区域，以及60Coγ光子。这些辐射的线能量转移（LET∞s）分别为90±5、35±3和0.3 keV/μm。辐照后，通过裂隙灯生物显微镜检查监测晶状体混浊的初期和/或临床阶段（小于或等于5年），并用主观但明确的指标进行评分。白内障的发生按照鲁宾和卡萨雷特（1968年）提出的模型进展，并受到辐射品质的如下影响：（1）早期（急性）阶段的发展速率随入射辐射的LET∞增加；（2）在中期（平台期）阶段，重离子的相对生物效应（r.b.e.）值与培养中增殖细胞的报告值相似；（3）对于给定的中期水平，辐射的LET亲和力越高，晚期白内障发生的起始越早。与脱发一样，白内障发生的r.b.e.s随辐照后时间而变化。
