Baloh R W, Yee R D, Honrubia V
Ann N Y Acad Sci. 1981;374:600-13. doi: 10.1111/j.1749-6632.1981.tb30904.x.
We studied electro-oculographic and videotape recordings of eye movements in six patients with Wallenberg's syndrome. With fixation, all patients had a spontaneous rotatory nystagmus with the fast phase directed toward the intact side. With loss of fixation, the patients' eyes deviated tonically toward the side of the lesion. Voluntary and involuntary saccades had larger amplitude when directed toward the side of the lesion than away from it. The spontaneous nystagmus predictably interacted with all slow eye movements, producing asymmetric smooth-pursuit, optokinetic, and vestibular responses. In addition, smooth-pursuit and optokinetic responses were decreased significantly in both directions compared to normal subjects. Fixation suppression of vestibular nystagmus also was impaired in both directions. We concluded that two different types of oculomotor bias were present in these patients--a velocity bias and a position bias. The former resulted from damage to the caudal lateral vestibular nuclei, and the latter from interruption of cerebellopontine pathways.
我们研究了6例患有瓦伦贝格综合征患者的眼电图和眼动录像。在注视时，所有患者均出现自发性旋转性眼球震颤，快相指向健侧。在失去注视时，患者的眼睛强直性地偏向病变侧。当向病变侧进行随意和不随意扫视时，其幅度比远离病变侧时更大。自发性眼球震颤可预测地与所有缓慢眼动相互作用，产生不对称的平稳跟踪、视动和前庭反应。此外，与正常受试者相比，平稳跟踪和视动反应在两个方向上均显著降低。前庭眼球震颤的注视抑制在两个方向上也受损。我们得出结论，这些患者存在两种不同类型的动眼偏斜——速度偏斜和位置偏斜。前者是由于尾侧外侧前庭核受损，后者是由于小脑脑桥通路中断。
