Aho K, Sistonen P, Takala J, Sievers K
Acta Med Scand. 1982 May;211(3):213-8. doi: 10.1111/j.0954-6820.1982.tb01929.x.
Familial occurrence of three types of autoantibodies, viz. rheumatoid factors, antinuclear antibodies and thyroid autoantibodies, was investigated in two population series: twins from the Finnish Twin Registry representing the adult twin population living in an urban area (76 monozygotic and 82 dizygotic same-sex twin pairs) and siblings from a middle-aged rural population subject to an ongoing epidemiological study (311 sibling groups comprising 801 subjects and 584 married couples). The observations were compatible with the concept of two components in the above autoantibody system. The major component is determined predominantly by environmental factors and is manifested with increasing age. The autoantibodies belonging to the minor, familial component occur in somewhat higher titers, exhibit certain specificity features of their own (RF reacting with rabbit gamma globulin), and are associated with "autoimmune" diseases.
在两个群体系列中研究了三种自身抗体（即类风湿因子、抗核抗体和甲状腺自身抗体）的家族发生率：来自芬兰双胞胎登记处的双胞胎，代表居住在城市地区的成年双胞胎群体（76对同卵双胞胎和82对同性异卵双胞胎），以及来自正在进行的流行病学研究的中年农村人口的兄弟姐妹（311个兄弟姐妹组，包括801名受试者和584对已婚夫妇）。这些观察结果与上述自身抗体系统中两个成分的概念相符。主要成分主要由环境因素决定，并随着年龄增长而显现。属于次要家族成分的自身抗体以略高的滴度出现，表现出自身特定的特征（类风湿因子与兔γ球蛋白反应），并与“自身免疫性”疾病相关。
