[Effect of hydrocortisone on the differentiation of B-lymphocytes in avian embryogenesis].

Hydrocortisone effect on B-lymphocytes differentiation in the avian bursa Fabricii has been studied in embryogenesis by means of the immunofluorescent method. Hydrocortisone (Flebocortid, the firm "Richter"), administered on the 11th day of the embryonal development in the dose 0.03 mg per one egg, blocks the differentiation process of cellular elements of the B-lymphoid line into mature lymphocytes containing immunoglobulins (IgM). When hydrocortisone is administered at the end of the embryonal development (on the 18th day of incubation) in the dose 1 mg, it is probably enhances migration processes of the B-lymphocytes from the central lymphoid organ (bursa Fabricii) into the peripheral ones (spleen), but dose not essentially affect the differentiation process of the lymphoid cells.