Hirota Y, Suzuki T, Bito Y
Immunology. 1980 Jan;39(1):29-36.
Chickens were treated with 4 mg of testosterone propionate on the twelfth day of embryonic life. Bursal remnants of testosterone-treated chickens were very small in size and had very few or no bursal follicles: the lymphoid tissue was replaced substantially by fibrosis. Testosterone-treated chickens formed almost exclusively IgM antibodies to sheep red blood cells and influenza virus, whereas no IgM or IgG response to Brucella abortus or Salmonella pullorum, and no IgG response to sheep red blood cells was demonstrable. Surgical removal of bursal remnants of testosterone-treated chickens at hatching did not significantly affect IgM response to sheep red blood cells. These B-cell functions of testosterone-treated chickens were not improved by addition of T cells, as shown by adoptive cell transfer experiments. Thus, there appears to be an unusual type B-cell development which is independent of the bursa of Fabricius.
在胚胎期第12天给鸡注射4毫克丙酸睾酮。经睾酮处理的鸡的法氏囊残余物体积非常小，几乎没有或完全没有法氏囊滤泡：淋巴组织基本上被纤维化所取代。经睾酮处理的鸡几乎只形成针对绵羊红细胞和流感病毒的IgM抗体，而对流产布鲁氏菌或鸡白痢沙门氏菌没有IgM或IgG反应，对绵羊红细胞也没有IgG反应。在孵化时手术切除经睾酮处理的鸡的法氏囊残余物，对其针对绵羊红细胞的IgM反应没有显著影响。如过继性细胞转移实验所示，添加T细胞并不能改善经睾酮处理的鸡的这些B细胞功能。因此，似乎存在一种不依赖于法氏囊的异常B细胞发育类型。
