Jones D F
Br J Anaesth. 1982 Jun;54(6):629-33. doi: 10.1093/bja/54.6.629.
Eighty unpremedicated patients received thiopentone and halothane, propanidid and fentanyl, diprivan (ICI 35 868) alone, or diprivan and fentanyl, each supplementing 66% nitrous oxide in oxygen. Diprivan alone, or in combination with fentanyl, resulted in a more rapid awakening than thiopentone and halothane, and significantly shorter recovery times than both thiopentone and halothane and propranidid and fentanyl. Administration of fentanyl with diprivan significantly reduced the total dose of the latter and all indices of recovery. Propanidid and fentanyl did not produce shorter overall recovery times than thiopentone and halothane but nausea and vomiting after operation were significantly increased when compared with the other techniques.
80名未用术前药的患者接受了硫喷妥钠和氟烷、丙泮尼地和芬太尼、单独使用二异丙酚(ICI 35 868)或二异丙酚与芬太尼,每种均补充66%的氧化亚氮-氧气混合气。单独使用二异丙酚或与芬太尼联合使用,导致苏醒比硫喷妥钠和氟烷更快,且恢复时间明显短于硫喷妥钠和氟烷以及丙泮尼地和芬太尼。芬太尼与二异丙酚联合使用显著降低了后者的总剂量以及所有恢复指标。丙泮尼地和芬太尼并未产生比硫喷妥钠和氟烷更短的总体恢复时间,但与其他技术相比,术后恶心和呕吐明显增加。