Davis W H, Lee S L, Sokoloff L
Arthritis Rheum. 1978 Sep-Oct;21(7):754-6. doi: 10.1002/art.1780210703.
The boundary lubricating ability of eleven synovial fluids was measured in a miniaturized latex--glass test system. The specimens were obtained at necropsy from knees in which the degree of degenerative joint disease varied from none to very severe. The lubricating ability of the fluid was independent of the viscosity over a wide range of shear rates. It was not diminished even in advanced lesions. In two additional fluids, the mucin clot was poor; the lubricating ability of one of these was compromised. Thus, although degenerative joint disease, during its quiescent stages, is not associated with defective synovial lubrication, the possibility that transient defects might lead to cartilage wear during life has not been excluded. The measurements are believed to be valid indicators of boundary lubricating ability under physiological conditions despite the fact that the test surfaces were not cartilaginous and the loading was relatively low (up to 47 pounds per square inch).
在一个小型乳胶-玻璃测试系统中测量了11种滑液的边界润滑能力。这些标本是在尸检时从膝关节获取的，其中退行性关节病的程度从无到非常严重不等。在很宽的剪切速率范围内，滑液的润滑能力与粘度无关。即使在晚期病变中，其润滑能力也没有降低。在另外两种滑液中，粘蛋白凝块较差；其中一种的润滑能力受到了损害。因此，尽管退行性关节病在静止期与滑膜润滑缺陷无关，但尚未排除短暂缺陷可能导致生命期间软骨磨损的可能性。尽管测试表面不是软骨的且负荷相对较低（每平方英寸高达47磅），但这些测量结果被认为是生理条件下边界润滑能力的有效指标。
