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肌肉收缩:通过高频刚度测量研究横桥附着动力学。

Muscular contraction: kinetics of crossbridge attachment studied by high-frequency stiffness measurements.

作者信息

Cecchi G, Griffiths P J, Taylor S

出版信息

Science. 1982 Jul 2;217(4554):70-2. doi: 10.1126/science.6979780.

DOI:10.1126/science.6979780
PMID:6979780
Abstract

Instantaneous stiffness of frog skeletal muscle, an indication of the proportion of attached crossbridges, was determined drug the tetanus rise and after a step length change imposed during the tetanus plateau. During the onset of contraction as well as after a step, the ratio of stiffness to force differed from that determined during the tetanus plateau. The data after a step are predicted by the Huxley-Simmons model of muscular contraction, but the results during the rise suggest that a long-lived state may exist between crossbridge attachment and force generation.

摘要

青蛙骨骼肌的瞬时刚度是附着横桥比例的一种指示,它是在强直收缩上升阶段以及在强直收缩平台期施加步长变化后测定的。在收缩开始时以及步长变化后,刚度与力的比值与在强直收缩平台期测定的不同。步长变化后的实验数据可由赫胥黎-西蒙斯肌肉收缩模型预测,但上升阶段的结果表明,在横桥附着和力产生之间可能存在一种长寿状态。

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