25-羟基维生素D3的24-羟化：它是雏鸡胚胎发育所必需的吗？

24-hydroxylation of 25-hydroxyvitamin D3: is it required for embryonic development in chicks?

作者信息

Ameenuddin S, Sunde M, DeLuca H F, Ikekawa N, Kobayashi Y

出版信息

Science. 1982 Jul 30;217(4558):451-2. doi: 10.1126/science.6979782.

Abstract

As shown previously, laying hens given 1,25-dihydroxyvitamin D3 as their sole source of vitamin D produce fertile eggs having normal shells, but only 35 to 55 percent of the embryos are normal. Giving these hens additional 25-hydroxyvitamin D3, 24,25-dihydroxyvitamin D3, or 24,24-difluoro-25-hydroxyvitamin D3 at 1.25 nanomoles per day resulted in 90 to 100 percent normal embryos, and hence, hatchability. Since 24,24-difluoro-25-hydroxyvitamin D3 cannot be 24-hydroxylated, 24-hydroxylation is not required for this function of 25-hydroxyvitamin D3.

摘要

如先前所示，以1,25 - 二羟基维生素D3作为唯一维生素D来源的产蛋母鸡产出的蛋具有正常的蛋壳且可育，但只有35%至55%的胚胎是正常的。每天给这些母鸡额外补充1.25纳摩尔的25 - 羟基维生素D3、24,25 - 二羟基维生素D3或24,24 - 二氟 - 25 - 羟基维生素D3，会使90%至100%的胚胎正常，从而孵化率也正常。由于24,24 - 二氟 - 25 - 羟基维生素D3不能进行24 - 羟化，所以25 - 羟基维生素D3的这一功能不需要24 - 羟化。