Liston T E, Foshee W S
South Med J. 1982 Jun;75(6):753-4. doi: 10.1097/00007611-198206000-00034.
Its virulence factors, immune responses, and sites of isolation characterize nontypable Haemophilus influenzae as a pathogen of mucosal surfaces which rarely causes invasive disease. We isolated nontypable H influenzae in pure culture from thoracentesis fluid in a child with pneumonia. An extensive review of the literature in which serotyping of H influenzae was reported revealed that nontypable strains have accounted for only six other cases of pneumonia diagnosed by blood culture, lung puncture, or thoracentesis fluid. The only isolate reported to cause disease outside the neonatal age group may have been a typable strain. Because this organism rarely causes invasive disease, its isolation from sputum is of questionable significance and other causes should be sought.
其毒力因子、免疫反应及分离部位表明，不可分型的流感嗜血杆菌是一种黏膜表面病原体，很少引起侵袭性疾病。我们从一名肺炎患儿的胸腔穿刺液中分离出了纯培养的不可分型流感嗜血杆菌。对报告有流感嗜血杆菌血清分型的文献进行广泛回顾发现，不可分型菌株仅在另外6例通过血培养、肺穿刺或胸腔穿刺液诊断的肺炎病例中出现过。据报道，唯一在新生儿年龄组以外引起疾病的分离株可能是可分型菌株。由于这种微生物很少引起侵袭性疾病，从痰液中分离出该菌的意义存疑，应寻找其他病因。
