Ray M B, Geboes K, Callea F, Desmet V J
Histopathology. 1982 May;6(3):289-97. doi: 10.1111/j.1365-2559.1982.tb02723.x.
Alpha-1-antitrypsin (AAT) was demonstrated in tumour cells in three out of five cases of gastric carcinoma showing the histological characteristics of carcinoid tumour. It was also detected in normal stomach mucosa, but was not found in 10 cases of adenocarcinoma of intestinal or mucous cell type. The AAT-positive tumour cells were argyrophilic, PAS-positive and were negative for pancreatic and gastric hormones. These findings suggest a possible malignant proliferation of alpha-1-antitrypsin-containing cells in the stomach.
在五例具有类癌组织学特征的胃癌病例中，有三例在肿瘤细胞中检测到α1抗胰蛋白酶（AAT）。在正常胃黏膜中也检测到了AAT，但在10例肠型或黏液细胞型腺癌中未发现。AAT阳性的肿瘤细胞嗜银、PAS阳性，对胰腺和胃激素呈阴性。这些发现提示胃中含α1抗胰蛋白酶的细胞可能发生恶性增殖。
